Evaluation of the Antiradiation Efficiency of Flagellin in Experiments on Mice

In experiments on SPF mice, the authors evaluated the radio-protective effectiveness of the recombinant Flagellin, developed at the Institute of High-Purity Preparations (St. Petersburg), administered at a wide range of doses of 0.004–2 mg/kg for 30 min prior to X-ray irradiation in the dose range o...

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Bibliographic Details
Published in:Biology bulletin of the Russian Academy of Sciences 2020-12, Vol.47 (11), p.1531-1535
Main Authors: Lisina, N. I., Shchegoleva, R. A., Shlyakova, T. G., Zorin, V. V., Shkayev, A. E., Rozhdestvensky, L. M.
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical and Life Sciences
Bone marrow
Cell Biology
Ecology
Flagellin
Life Sciences
Life span
Modification of Radiation Effects
Zoology
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Summary:In experiments on SPF mice, the authors evaluated the radio-protective effectiveness of the recombinant Flagellin, developed at the Institute of High-Purity Preparations (St. Petersburg), administered at a wide range of doses of 0.004–2 mg/kg for 30 min prior to X-ray irradiation in the dose range of 7–10 Gy. The effectiveness of Flagellin was evaluated in terms of 30-day survival rates of the mice, the average life expectancy, and according to the DMF criterion for bone marrow death. The DMF values were 1.24–1.23–1.22 at the level of LD 16 , LD 50 , and LD 84 . ED 50 approximately equals 25 μg/kg. The dose-response effect of Flagellin was evaluated to reach a plateau at a dose of 0.2 mg/kg.
ISSN:1062-3590
1608-3059
DOI:10.1134/S1062359020110084