Cell primitive-based biomimetic functional materials for enhanced cancer therapy

Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. Cell primitives are characterized by distinctive biological functions, such as long-term circulation, tumor specific target...

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Bibliographic Details
Published in:Chemical Society reviews 2021-01, Vol.5 (2), p.945-985
Main Authors: Luo, Guo-Feng, Chen, Wei-Hai, Zeng, Xuan, Zhang, Xian-Zheng
Format: Article
Language:English
Subjects:
Anticancer properties
Biocompatibility
Biological activity
Biomedical materials
Biomimetic materials
Cancer therapies
Cell membranes
Chemical compounds
Chemical properties
Functional materials
Nanomaterials
Nanotechnology
Phages
Pharmacology
Therapy
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Summary:Cell primitive-based functional materials that combine the advantages of natural substances and nanotechnology have emerged as attractive therapeutic agents for cancer therapy. Cell primitives are characterized by distinctive biological functions, such as long-term circulation, tumor specific targeting, immune modulation etc. Moreover, synthetic nanomaterials featuring unique physical/chemical properties have been widely used as effective drug delivery vehicles or anticancer agents to treat cancer. The combination of these two kinds of materials will catalyze the generation of innovative biomaterials with multiple functions, high biocompatibility and negligible immunogenicity for precise cancer therapy. In this review, we summarize the most recent advances in the development of cell primitive-based functional materials for cancer therapy. Different cell primitives, including bacteria, phages, cells, cell membranes, and other bioactive substances are introduced with their unique bioactive functions, and strategies in combining with synthetic materials, especially nanoparticulate systems, for the construction of function-enhanced biomaterials are also summarized. Furthermore, foreseeable challenges and future perspectives are also included for the future research direction in this field. This review provides a comprehensive understanding of the combination of cell primitives and synthetic materials for constructing function-enhanced hybrid materials in the fight against cancer.
ISSN:0306-0012
1460-4744
DOI:10.1039/d0cs00152j