Investigation of a healthcare-associated candida infections in a Turkish intensive care unit: risk factors, therapy and clinical outcome

• Published in: Experimental biomedical research 2021-01, Vol.4 (1), p.9-15
• Main Authors: Sirmatel, Fatma, Behcet, Mustafa, Ozarslan, Ogulcan, Gozdas, Hasan Tahsin, Avcioglu, Fatma
• Format: Article
• Language: English
• Subjects: Antibiotics; Candida; Candidemia; Candidiasis; Fungi; Infections; Intensive care; Investigations; Mortality; Patients; Risk factors; Sağlık Hizmetleri; Species; Tıp; β-Lactam antibiotics
• ISSN: 2618-6454; 2618-6454
• DOI: 10.30714/j-ebr.2021165773

Aim: Candida infections develop especially in intensive care unit (ICU) patients and increase the mortality rates. So, early and accurate diagnosis of Candida infections and determination of risk factors are very important. We aimed to retrospectively investigate Candida infections in terms of species and risk factors for candidemia caused by fungi. Methods: Candida infections in critically ill patients hospitalized in the Intensive Care Unit of Bolu Abant Izzet Baysal University Training and Research Hospital between January 2014 and December 2018 were retrospectively analyzed. The isolated Candida species were evaluated according to the sample types. The cases were investigated in terms of mortality due to candidiasis, previously used antibiotics and isolated Candida species. Results: 34 Candida species isolated from fungal cultures in ICUs were included in the study. Candida albicans (73.5%) was the most prevalent species isolated (NAC 26.5%). Patients with Candida isolated in their urine samples (76%) had a higher mortality rate than patients with Candida from other regions. Conclusion: The results of our study suggest that the highest rate of candidiasis (88%) is in patients who received beta-lactam antibiotic treatment. In addition, we think that when Candida species are detected in the urine samples of critically ill patients in the ICU, care should be taken in terms of candidiasis.