Asymmetric Oxidative Mannich Reactions

The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have bee...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2021-02, Vol.363 (3), p.602-628
Main Authors: Rostoll‐Berenguer, Jaume, Blay, Gonzalo, Pedro, José R., Vila, Carlos
Format: Article
Language:English
Subjects:
Amines
asymmetric catalysis
Asymmetry
cross-dehydrogenative coupling
Enantiomers
Imines
Mannich reaction
oxidation
Oxidizing agents
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Summary:The asymmetric Mannich reaction is one of the most straightforward methodologies for the enantioselective synthesis of chiral amines. In general, asymmetric Mannich reactions involve the use of imines as electrophiles. However, in recent years, several asymmetric oxidative Mannich reactions have been reported using amines as electrophiles. This review provides an overview of these recent publications, including the different oxidants used and the scope and limitations of the different catalytic systems.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202001017