Being on the side of old findings: progesterone elevation on the day of oocyte maturation induction does not affect embryological parameters throughout the blastocyst culture period

• Published in: Archives of gynecology and obstetrics 2021-02, Vol.303 (2), p.581-587
• Main Authors: Turgut, Emre Niyazi, Ecemis, Selen, Boynukalin, Kubra Fazilet, Gultomruk, Meral, Yarkiner, Zalihe, Findikli, Necati, Bahceci, Mustafa
• Format: Article
• Language: English
• Subjects: Adult; Blastocyst; Cohort Studies; Embryo Culture Techniques; Embryonic Development - drug effects; Embryos; Endocrinology; Endometrium; Female; Fertilization in Vitro; Gene expression; Gynecologic Endocrinology and Reproductive Medicine; Gynecology; Hormone Antagonists - pharmacology; Human Genetics; Humans; Medicine; Medicine & Public Health; Obstetrics/Perinatology/Midwifery; Oocytes - drug effects; Oogenesis - drug effects; Ovaries; Pregnancy; Progesterone - blood; Progesterone - pharmacology; Retrospective Studies; Sperm; Sperm Injections, Intracytoplasmic
• ISSN: 0932-0067; 1432-0711
• DOI: 10.1007/s00404-020-05792-z

Purpose To investigate whether there is any detrimental effect of progesterone elevation (PE) on the day of oocyte maturation induction on embryological development potentials. Methods This retrospective single-center cohort study included a total of 1485 individual intracytoplasmic sperm injection (ICSI) cycles between January 2014 and December 2018. Serum progesterone (P) levels were measured on the day of oocyte maturation induction following the GnRH antagonist suppression protocol. Embryological parameters such as maturation, fertilization rate (FR), top-quality embryo (TQE) formation rate per 2PN on day 3, and excellent-quality blastocyst (EQB) formation rate per 2PN on day 5/6 were recorded. The inclusion criteria for women were an age ≤ 37 years, a BMI ≤ 30 kg/m 2 , and access to a total sperm concentration ≥ 2 million. Groups were stratified according to the serum P levels using the cut-off levels of