Synthesis of 4,4′-Oxydibenzoic Acid Amides and Sulfonamides Containing 2-Arylaminopyrimidine Moieties

New 4,4′-oxydibenzamides and sulfamoyl derivatives of 4,4′-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the amide moiety have been synthesized. Acylation of amines of the pyrimidine series with 2-chlorosulfonyl-substituted 4,4′-oxydibenzoic acid gave the correspondi...

Full description

Saved in:
Bibliographic Details
Published in:Russian journal of organic chemistry 2020-12, Vol.56 (12), p.2092-2097
Main Authors: Ignatovich, Zh. V., Ermolinskaya, A. L., Petushok, V. G., Katok, Ya. M., Koroleva, E. V.
Format: Article
Language:English
Subjects:
Acylation
Amides
Amines
Aniline
Chemistry
Chemistry and Materials Science
Chlorides
Derivatives
Organic Chemistry
Sulfonamides
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:New 4,4′-oxydibenzamides and sulfamoyl derivatives of 4,4′-oxydibenzoic acid containing pharmacophoric 2-arylaminopyrimidine fragments in the amide moiety have been synthesized. Acylation of amines of the pyrimidine series with 2-chlorosulfonyl-substituted 4,4′-oxydibenzoic acid gave the corresponding sulfonamides. Arylaminopyrimidine derivatives of 4,4′-oxydibenzamide were obtained in 75–87% yield by acylation of 3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}anilines with 4,4′-oxydibenzoyl chloride. The reactivity of 4,4′-oxydibenzoyl chloride toward amines is discussed.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428020120076