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Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica
An efficient and facile method has been developed for the synthesis of various 6,6 a -dihydroisoindolo[2,1- a ]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino- N -(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as...
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Published in: | Monatshefte für Chemie 2021, Vol.152 (1), p.103-107 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | An efficient and facile method has been developed for the synthesis of various 6,6
a
-dihydroisoindolo[2,1-
a
]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino-
N
-(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method.
Graphic abstract |
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ISSN: | 0026-9247 1434-4475 |
DOI: | 10.1007/s00706-020-02720-4 |