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Efficient synthesis of 6,6a-dihydroisoindolo[2,1-a]quinazoline-5,11-dione derivatives catalyzed by functionalized nanoporous silica

An efficient and facile method has been developed for the synthesis of various 6,6 a -dihydroisoindolo[2,1- a ]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino- N -(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as...

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Bibliographic Details
Published in:Monatshefte für Chemie 2021, Vol.152 (1), p.103-107
Main Authors: Rayatzadeh, Ayeh, Haghipour, Sirous
Format: Article
Language:English
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Summary:An efficient and facile method has been developed for the synthesis of various 6,6 a -dihydroisoindolo[2,1- a ]quinazoline-5,11-dione derivatives, via a three-component reaction of 2-amino- N -(R)-benzamide derivatives with 2-formylbenzoic acid using sulfonic acid functionalized nanoporous silica as an efficient catalyst in ethanol under reflux. High yield of the desired products, reusability of the catalyst, and effortless workup step without using chromatography are the advantages of this method. Graphic abstract
ISSN:0026-9247
1434-4475
DOI:10.1007/s00706-020-02720-4