Mycobacterium bovis and you: A comprehensive look at the bacteria, its similarities to Mycobacterium tuberculosis, and its relationship with human disease

While Mycobacterium tuberculosis is the primary cause of tuberculosis in people, multiple other mycobacteria are capable of doing so. With the World Health Organization's goal of a 90% reduction in tuberculosis by 2035, all tuberculous mycobacteria need to be addressed. Understanding not only t...

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Bibliographic Details
Published in:Tuberculosis (Edinburgh, Scotland) Scotland), 2020-12, Vol.125, p.102006, Article 102006
Main Authors: Kanipe, Carly, Palmer, Mitchell V.
Format: Article
Language:English
Subjects:
Bacteria
Genomes
Host preferences
Human-animal interface
Immune response
Infections
Medical treatment
Mycobacterium bovis
Mycobacterium tuberculosis
One health
Similarity
Tuberculosis
Zoonotic tuberculosis
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Summary:While Mycobacterium tuberculosis is the primary cause of tuberculosis in people, multiple other mycobacteria are capable of doing so. With the World Health Organization's goal of a 90% reduction in tuberculosis by 2035, all tuberculous mycobacteria need to be addressed. Understanding not only the similarities, but importantly the differences between the different species is crucial if eradication is ever to be achieved. Mycobacterium bovis, while typically thought of as a disease of cattle, remains a possible source of human infection worldwide. Although this species' genome differs from Mycobacterium tuberculosis by only 0.05%, significant differences are present, creating unique challenges to address. This review focuses on features which distinguish this bacterium from Mycobacterium tuberculosis, including differences in origin, structure, environmental persistence, host preferences, infection and disease, host immune response, diagnostics and treatment.
ISSN:1472-9792
1873-281X
DOI:10.1016/j.tube.2020.102006