Urinary clusterin and cystatin B as biomarkers of tubular injury in dogs following envenomation by the European adder

Diagnosing acute kidney injury remains a challenge since the established renal biomarkers, serum creatinine (sCr) and symmetric dimethylarginine (SDMA) reflect glomerular function and not tubular injury. Sensitive tubular markers such as urinary clusterin (uClust) and cystatin B (uCysB) have been pr...

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Bibliographic Details
Published in:Research in veterinary science 2021-01, Vol.134, p.12-18
Main Authors: Gordin, E., Gordin, D., Viitanen, S., Szlosek, D., Coyne, M., Farace, G., Murphy, R., Quinn, J., Yerramilli, Ma, Yerramilli, Mu, Spillmann, T.
Format: Article
Language:English
Subjects:
Acute kidney injury
Acute Kidney Injury - blood
Acute Kidney Injury - diagnosis
Acute Kidney Injury - urine
Acute Kidney Injury - veterinary
Animals
Arginine - analogs & derivatives
Arginine - blood
Arginine - urine
Biomarkers
Biomarkers - blood
Biomarkers - urine
Canine
Case-Control Studies
Clusterin
Clusterin - blood
Clusterin - urine
Cohort Studies
Correlation analysis
Creatinine
Creatinine - urine
Cystatin B - blood
Cystatin B - urine
Cystatins
Dog Diseases - blood
Dog Diseases - urine
Dogs
Envenomation
European adder
Female
Injuries
Kidney Function Tests
Kidneys
Laboratories
Male
Prospective Studies
Proteins
Retrospective Studies
Snake Bites - complications
Snake Bites - urine
Snake Bites - veterinary
Snakes
Tubular biomarker
Urine
Venom
Veterinary medicine
Viperidae
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Summary:Diagnosing acute kidney injury remains a challenge since the established renal biomarkers, serum creatinine (sCr) and symmetric dimethylarginine (SDMA) reflect glomerular function and not tubular injury. Sensitive tubular markers such as urinary clusterin (uClust) and cystatin B (uCysB) have been proposed to detect AKI at an earlier stage. Since envenomation by the European adder (Vipera berus berus) could serve as a spontaneous disease model of AKI we investigated these new biomarkers in affected dogs. Concentrations of uClust and uCysB as well as sCr and SDMA were analyzed retrospectively in stored samples from 26 dogs with snake envenomation and 13 healthy controls. Higher concentrations of uClust (P 
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2020.11.019