Design and synthesis of novel 1,3,4‐oxadiazole based azaspirocycles catalyzed by NaI under mild condition and evaluated their antidiabetic and antibacterial activities

A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series of 1,3,4‐oxadiazole containing azaspirocycles derivatives. The reaction of 1,3,4‐oxadiazole derivative with diverse azaspiro compounds under room temperature condition with helps of sodium iodide c...

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Published in:Journal of heterocyclic chemistry 2021-02, Vol.58 (2), p.612-621
Main Authors: Radia, Ashish J., Lalpara, Jaydeep N., Modasiya, Ishita J., Dubal, Gaurang G.
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Language:English
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Oxadiazoles
Room temperature
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description A modest, efficient, and mild synthetic procedure has been developed for the synthesis of novel series of 1,3,4‐oxadiazole containing azaspirocycles derivatives. The reaction of 1,3,4‐oxadiazole derivative with diverse azaspiro compounds under room temperature condition with helps of sodium iodide catalyst and polar aprotic solvent. Numerous compensations of this strategy embrace less time required, yield increment, consumption of all reactants, and mild condition. All synthesized compounds evaluated for in vitro antidiabetic and antibacterial screening. Among them some compounds show significant biological response.
doi_str_mv 10.1002/jhet.4200
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subjects Oxadiazoles
Room temperature
title Design and synthesis of novel 1,3,4‐oxadiazole based azaspirocycles catalyzed by NaI under mild condition and evaluated their antidiabetic and antibacterial activities
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