Indazole scaffold: a generalist for marketed and clinical drugs

More and more attention has been paid to the structurally diverse indazole analogs in recent years which are widely present in numerous commercially available drugs. Indazole-containing derivatives are endowed with a broad range of biological properties, such as anti-inflammatory, antibacterial, ant...

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Bibliographic Details
Published in:Medicinal chemistry research 2021-03, Vol.30 (3), p.501-518
Main Authors: Cao, Yaquan, Luo, Chunying, Yang, Pu, Li, Pan, Wu, Chunli
Format: Article
Language:English
Subjects:
Anticancer properties
Biochemistry
Biological properties
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Fungicides
HIV
Human immunodeficiency virus
Inflammation
Inorganic Chemistry
Medicinal Chemistry
Pharmacology/Toxicology
Review Article
Scaffolds
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Summary:More and more attention has been paid to the structurally diverse indazole analogs in recent years which are widely present in numerous commercially available drugs. Indazole-containing derivatives are endowed with a broad range of biological properties, such as anti-inflammatory, antibacterial, anti-HIV, antiarrhythmics, antifungal and antitumor activities. This review is a guide for pharmacologists who are in search of valid preclinical/clinical drug compounds where the progress, from 1966 to the present day, of approved marketed drugs containing indazole scaffold is examined.
ISSN:1054-2523
1554-8120
DOI:10.1007/s00044-020-02665-7