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Achieving synergistically enhanced dual-mode electrochemiluminescent and electrochemical drug sensors via a multi-effect porphyrin-based metal-organic framework
•Dual-mode electrochemiluminescent and electrochemical drug sensors are designed.•Zinc based porphyrin MOF as a luminophore gives high electrochemiluminescent signal.•Prepared MOF as an electrochemical redox probe shows well electrocatalytic activity.•l-penicillamine capped Au nanoparticles display...
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Published in: | Sensors and actuators. B, Chemical Chemical, 2021-03, Vol.330, p.129388, Article 129388 |
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Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Dual-mode electrochemiluminescent and electrochemical drug sensors are designed.•Zinc based porphyrin MOF as a luminophore gives high electrochemiluminescent signal.•Prepared MOF as an electrochemical redox probe shows well electrocatalytic activity.•l-penicillamine capped Au nanoparticles display good specificity for S-naproxen.•The sensors exhibit high sensitivity and selectivity for the detection of S-naproxen.
Since the sensing methods in drug detection are commonly hampered by signal capacity limitations and sole analysis information, dual-mode sensors with high accuracy and flexibility have become more popular. Herein, we present a two-dimensional porphyrin-based metal-organic framework (ZnTCPP MOF) as a unique electrochemiluminescent (ECL) and electrochemical (EC) dual-signal indicator, combined with L-penicillamine-capped Au nanoparticles (L-Pen-Au NPs) as a specific selector, to construct an innovative dual-mode drug sensing platform. Inspired by the optical and electrocatalytic activity of 5,10,15,20-tetrakis-(4-carboxyphenyl)porphyrin (TCPP), a series of ZnTCPP MOFs have been synthesized through a facile bottom-up method. Among them, the “oval-like” ZnTCPP MOF generates higher ECL responses than TCPP monomer when acting as a near-infrared luminophore and outputs stronger EC signals when acting as a redox active probe. In addition, the ZnTCPP MOF, when employed as a nanocarrier, can load many L-Pen-Au NPs. Using L-Pen-Au NPs as selectors, synergistically enhanced dual-mode sensors for detection of the anti-inflammatory drug S-naproxen (S-NAP) exhibit versatile and superior performance and a wide linear range with an ultralow limit of detection. We believe that the applications of this dual-mode sensor can be readily expanded to become a universal platform for sensitive detection of different types of drugs by changing the selector. |
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ISSN: | 0925-4005 1873-3077 |
DOI: | 10.1016/j.snb.2020.129388 |