Therapeutic Effects of Curcumol in Several Diseases; An Overview

Curcumae Rhizoma, also known as Ezhu is a traditional Chinese medicine that has been used for many centuries against several diseases. The rhizome of the plant is composed of curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin), and essential volatile oils including curcumol, curdion...

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Published in:Nutrition and cancer 2021, Vol.73 (2), p.181-195
Main Authors: Hashem, Sheema, Nisar, Sabah, Sageena, Geetanjali, Macha, Muzafar A., Yadav, Santosh K., Krishnankutty, Roopesh, Uddin, Shahab, Haris, Mohammad, Bhat, Ajaz A.
Format: Article
Language:English
Subjects:
AKT protein
Anticancer properties
Antiinfectives and antibacterials
Antioxidant
Antioxidants
Apoptosis
Aquatic plants
Breast
Cancer
cancer prevention
Cell proliferation
Cell survival
Chemical composition
Chemical compounds
Curcumin
Cytotoxicity
dietary intervention
Drug development
Essential oils
Head and neck
Herbal medicine
Inflammation
Lung cancer
MAP kinase
Metastases
NF-κB protein
Oxidative stress
Pharmaceuticals
Rhizomes
Solid tumors
Terpenes
Toxicity
Traditional Chinese medicine
transcription factors
Tumors
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Summary:Curcumae Rhizoma, also known as Ezhu is a traditional Chinese medicine that has been used for many centuries against several diseases. The rhizome of the plant is composed of curcuminoids (curcumin, demethoxycurcumin, and bisdemethoxycurcumin), and essential volatile oils including curcumol, curdione, and germacrone. While curcuminoids have been extensively studied for their antimicrobial, antioxidant, anti-inflammatory and anticancer properties, the therapeutic efficacy of curcumol is still emerging. Recent studies have shown anticancer properties of curcumol against multiple solid tumors such as breast, colorectal, head and neck, and lung adenocarcinomas. The underlying anti-tumor mechanisms revealed inhibition of several signaling pathways (NF-κB, MAPK, PI-3K/AKT, and GSK-3β) associated with cell proliferation, survival, anti-apoptosis, invasion and metastasis. Besides curcumol, extracts from the Curcumae Rhizoma roots possess many other terpenoids such as β-elemene, δ-elemene, germacrone, furanodiene and furanodienone with known anticancer properties. In this review, we comprehensively focused on the composition of Curcumae Rhizoma essential oils, their structure, isolation and therapeutic uses of curcumol to aid in the improvement and development of novel drugs with minimal cytotoxicity, enhanced efficacy, and less cost.
ISSN:0163-5581
1532-7914
DOI:10.1080/01635581.2020.1749676