Prototype system of noninterferometric phase-contrast computed tomography utilizing medical imaging components

• Published in: Journal of applied physics 2021-02, Vol.129 (7)
• Main Authors: Wu, Z., Wei, W. B., Gao, K., Liu, G., Liu, G. F., Sun, H. X., Jiang, J., Wang, Q. P., Lu, Y. L., Tian, Y. C.
• Format: Article
• Language: English
• Subjects: Applied physics; Computed tomography; Field of view; High aspect ratio; Image contrast; Medical imaging; Optimization; Prototypes; Soft tissues; Synchrotron radiation; Synchrotrons; Tomography; X ray imagery
• ISSN: 0021-8979; 1089-7550
• DOI: 10.1063/5.0031392

Grating-based x-ray phase-contrast imaging has been demonstrated to provide more information and higher-contrast images for low-Z soft tissues, compared with conventional absorption-based imaging. However, the existing Talbot–Lau phase-contrast devices are operated in either a two- or three-dimensional mode at low energy with a small field of view and long exposure time. This is because of coherence limitations, difficulties in fabricating high aspect ratio gratings, and the slow readout speed of the detector. For preclinical or even clinical applications, a variable x-ray energy, a large field of view, and fast phase-contrast computed tomography (CT) devices are desirable. The noninterferometric grating-based phase-contrast imaging method is a good candidate, as it relaxes requirements on gratings, including grating period and aspect ratio. Based on the noninterferometric imaging principle, we constructed a prototype phase-contrast CT system, at the National Synchrotron Radiation Laboratory of the University of Science and Technology of China, with medical imaging components. This prototype system enables a large field of view and fast phase-contrast CT imaging under medical imaging energies. In this paper, the prototype system and preliminary experimental results are reported, and possible optimization for forthcoming work is also discussed.