Effect of macrocyclic lactones on nontarget coprophilic organisms: a review

Macrocyclic lactones are frequently used dewormers in livestock farms around the world. Due to their wide spectrum of action against nematodes and arthropods and their practicality of application at very low doses, their use has become massive since their discovery. These compounds are eliminated in...

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Bibliographic Details
Published in:Parasitology research (1987) 2021-03, Vol.120 (3), p.773-783
Main Authors: Junco, M., Iglesias, L. E., Sagués, M. F., Guerrero, I., Zegbi, S., Saumell, C. A.
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - chemistry
Antiparasitic Agents - pharmacology
Antiparasitic Agents - toxicity
Arthropods - drug effects
Arthropods - physiology
Biomedical and Life Sciences
Biomedicine
Cattle
Domestic animals
Dung
Farms
Feces
Feces - parasitology
Helminthology - Review
Immunology
Lactones
Lactones - chemistry
Lactones - pharmacology
Lactones - toxicity
Livestock
Livestock farms
Medical Microbiology
Microbiology
Nematoda - drug effects
Nematoda - physiology
Side effects
Soil - parasitology
Soil Pollutants - chemistry
Soil Pollutants - toxicity
Standardization
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Summary:Macrocyclic lactones are frequently used dewormers in livestock farms around the world. Due to their wide spectrum of action against nematodes and arthropods and their practicality of application at very low doses, their use has become massive since their discovery. These compounds are eliminated in a large percentage in the feces of animals, causing adverse effects on coprophilic fauna. Several research groups around the world have been devoted to evaluating these effects on this fauna. The aim of this review is to register the adverse effects of the concentrations in which macrocyclic lactones are eliminated in the feces of domestic animals and the importance of the coprophilic and edaphilous fauna on the degradation of the feces of the animals. The documented data shows that the use of macrocyclic lactones has a high toxicological risk for the different species that colonize the dung, thus causing an adverse effect on its disintegration and its subsequent incorporation into the soil. Even so, more studies at the regional level and their standardization are necessary to make the comparison between different areas possible.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-021-07064-4