Review of Direct Oral Anticoagulants and Guide for Effective Drug Utilization

Direct oral anticoagulants (DOACs) have been developed as a viable and in some cases superior alternative to warfarin. These agents have overcome some of the limitations of warfarin, which has a narrow therapeutic window and many food and drug interactions. DOACs have been demonstrated to have a mor...

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Bibliographic Details
Published in:American journal of cardiovascular drugs : drugs, devices, and other interventions devices, and other interventions, 2019-12, Vol.19 (6), p.525-539
Main Authors: Khachatryan, Tigran, Hauschild, Christopher, Hoff, Jason, Contractor, Tahmeed, Khachatryan, Arthur, Tran, Huyentran, Matsuo, Bert, Jacobson, Alan, Hilliard, Anthony
Format: Article
Language:English
Subjects:
Anticoagulants
Cardiology
Contraindications
Decision making
Drug dosages
Drug interactions
FDA approval
Medicine
Medicine & Public Health
Patients
Pharmacology
Pharmacology/Toxicology
Pharmacotherapy
Review Article
Stroke
Thromboembolism
Thrombosis
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Summary:Direct oral anticoagulants (DOACs) have been developed as a viable and in some cases superior alternative to warfarin. These agents have overcome some of the limitations of warfarin, which has a narrow therapeutic window and many food and drug interactions. DOACs have been demonstrated to have a more predictable and reliable pharmacology and, unlike warfarin, do not require frequent monitoring of anticoagulant effect. For these reasons, the use of DOACs is increasing. Despite the many positive attributes of these agents, limitations and contraindications do exist. An understanding of the pharmacology, indications, and contraindications is therefore crucial for effective patient management. We review the available agents to aid in effective drug utilization.
ISSN:1175-3277
1179-187X
DOI:10.1007/s40256-019-00344-6