Osteogenic differentiation of mesenchymal stem cells on the bimodal polymer polyurethane/polyacrylonitrile containing cellulose phosphate nanowhisker

Polycaprolactone diol is the cornerstone, equipped with polyacrylonitrile and cellulose nanowhiskers (CNWs), of biocompatible and biodegradable polyurethanes (PUs). The solvent casting/particulate leaching technique was employed to contracting foam scaffolds with bimodal sizes from the combination o...

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Bibliographic Details
Published in:Human cell : official journal of Human Cell Research Society 2021-03, Vol.34 (2), p.310-324
Main Authors: Padash, Arash, Halabian, Raheleh, Salimi, Ali, Kazemi, Negar Motakef, Shahrousvand, Mohsen
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradability
Biomedical and Life Sciences
Cell Biology
Cell differentiation
Cellulose
Cytotoxicity
Extracellular matrix
Gynecology
Leaching
Life Sciences
Mesenchymal stem cells
Nanocomposites
Oncology
Polyacrylonitrile
Polycaprolactone
Polymers
Polyurethane
Reproductive Medicine
Research Article
Sodium chloride
Stem Cells
Surgery
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Summary:Polycaprolactone diol is the cornerstone, equipped with polyacrylonitrile and cellulose nanowhiskers (CNWs), of biocompatible and biodegradable polyurethanes (PUs). The solvent casting/particulate leaching technique was employed to contracting foam scaffolds with bimodal sizes from the combination of polyurethane/polyacrylonitrile/cellulose nanowhisker nanocomposites. Sugar and sodium chloride are components used as porogens to develop the leaching method and fabricate the 3D scaffolds. Incorporation of different percentages of cellulose nanowhisker leads to the various efficient structures with biodegradability and biocompatibility properties. All nanocomposites scaffolds, as revealed by MTT assay using mesenchymal stem cell (MSC) lines, were non-cytotoxic. PU/PAN/CNW foam scaffolds were used for osteogenic differentiation of human mesenchymal stem cells (hMSCs). Based on the results, PU/PAN/CNW nanocomposites could not only support osteogenic differentiation but can also enhance the proliferation of hMSCs in three-dimensional synthetic extracellular matrix. Graphic abstract
ISSN:1749-0774
0914-7470
1749-0774
DOI:10.1007/s13577-020-00449-0