Linear porokeratosis with bone abnormalities treated with compounded topical 2% cholesterol/2% lovastatin ointment

We describe a case of linear porokeratosis with associated bone resorption in a 17‐year‐old female with marked improvement after 2% cholesterol/2% lovastatin ointment application. Porokeratosis is a heterogenous group of keratinization disorders characterized by a cornoid lamella, consisting of foca...

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Bibliographic Details
Published in:Pediatric dermatology 2021-01, Vol.38 (1), p.242-245
Main Authors: Blue, Elliot, Abbott, James, Bowen, Anneli, Cipriano, Sarah D.
Format: Article
Language:English
Subjects:
Adolescent
Bone diseases
Bone resorption
Case reports
Cholesterol
Epidermis
Female
Humans
Keratin
Keratinization
linear porokeratosis
Lovastatin
Metabolites
Mevalonic acid
Ointments
Pediatrics
porokeratosis
Porokeratosis - diagnosis
Porokeratosis - drug therapy
porokeratotic adnexal ostial nevus (PAON)
Skin diseases
Topical medication
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Summary:We describe a case of linear porokeratosis with associated bone resorption in a 17‐year‐old female with marked improvement after 2% cholesterol/2% lovastatin ointment application. Porokeratosis is a heterogenous group of keratinization disorders characterized by a cornoid lamella, consisting of focal dyskeratotic cells in the granular layer and columns of parakeratosis. The pathogenesis of porokeratosis is not fully elucidated; however, germline mutations have recently been identified in the mevalonate pathway which can lead to a buildup of metabolites that could play a role in dysmaturation. There has only been one prior report of an affected distal digit with underlying bone resorption in association with linear porokeratosis.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.14447