Heck’s disease occurring after Epstein‐Barr virus‐associated smooth muscle tumors in an immunosuppressed child

A 10‐year‐old Guatemalan girl with past medical history of Epstein‐Barr virus‐associated smooth muscle tumors (EBV‐SMT) and combined immunodeficiency presented for evaluation of painful intraoral lesions. On examination, she was noted to have multiple, white to flesh‐colored, soft, flat‐topped papul...

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Bibliographic Details
Published in:Pediatric dermatology 2021-01, Vol.38 (1), p.257-259
Main Authors: Arbelo‐Ramos, Natasha, Anderson, Katelyn, Joshi, Avni, Wieland, Carilyn, Tyring, Stephen, Rady, Peter, Tollefson, Megha
Format: Article
Language:English
Subjects:
Cancer
Case reports
Child
Epstein-Barr virus
Epstein-Barr Virus Infections - complications
Epstein-Barr Virus Infections - diagnosis
Female
Focal Epithelial Hyperplasia
Heck's disease
Herpesvirus 4, Human
Human papillomavirus
Humans
Hyperplasia
Immunodeficiency
Mouth Mucosa
Mucosa
Muscular system
Papillomaviridae
Pediatrics
Plaques
Smooth muscle
Smooth Muscle Tumor - diagnosis
Tumors
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Summary:A 10‐year‐old Guatemalan girl with past medical history of Epstein‐Barr virus‐associated smooth muscle tumors (EBV‐SMT) and combined immunodeficiency presented for evaluation of painful intraoral lesions. On examination, she was noted to have multiple, white to flesh‐colored, soft, flat‐topped papules, and plaques on the buccal and labial mucosa. Human papillomavirus type 13 was detected on PCR with PGMY primers of previously biopsied buccal tissue, confirming a diagnosis of Heck's disease (multifocal epithelial hyperplasia). We present an immunosuppressed, pediatric patient with two rare, virus‐associated neoplastic disorders that have not been previously reported to occur in the same individual.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.14463