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Pd-Catalyzed asymmetric allylation involving bis(diamidophosphite) based on the salen-type chiral diamine
New bis(diamidophosphite) ligand with stereogenic phosphorus atoms in the 1,3,2-diaza-phospholidine rings was synthesized based on (1 R ,2 R )-[ N, N ′-bis(3-hydroxybenzylidene)]-1,2-diaminocyclohexane. This ligand provided up to 73% ee in Pd-catalyzed asymmetric allylic alkylation of ( E )-1,3-diph...
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Published in: | Russian chemical bulletin 2021-02, Vol.70 (2), p.336-339 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | New bis(diamidophosphite) ligand with stereogenic phosphorus atoms in the 1,3,2-diaza-phospholidine rings was synthesized based on (1
R
,2
R
)-[
N, N
′-bis(3-hydroxybenzylidene)]-1,2-diaminocyclohexane. This ligand provided up to 73%
ee
in Pd-catalyzed asymmetric allylic alkylation of (
E
)-1,3-diphenylallyl acetate with dimethyl malonate and up to 80%
ee
in its amination with pyrrolidine, with the starting substrate conversion being quantitative. |
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ISSN: | 1066-5285 1573-9171 |
DOI: | 10.1007/s11172-021-3090-x |