Surgical resection of gastrointestinal stromal tumor of esophagus following preoperative imatinib treatment: a case report

We report a case of esophagectomy after a primary esophageal gastrointestinal stromal tumor (GIST) was preoperatively treated with imatinib mesylate. A 71-year-old woman was diagnosed with an esophageal submucosal tumor by upper gastrointestinal endoscopy at her health checkup. The tumor was located...

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Bibliographic Details
Published in:Esophagus : official journal of the Japan Esophageal Society 2010-03, Vol.7 (1), p.65-69
Main Authors: Sato, Hiroki, Kanda, Tatsuo, Hirota, Seiichi, Bamba, Takeo, Sakamoto, Kaoru, Kosugi, Shin-ichi, Matsuki, Atsushi, Mashima, Yasuoki, Watanabe, Gen, Hatakeyama, Katsuyoshi
Format: Article
Language:English
Subjects:
Case Report
Case reports
Endoscopy
Esophageal cancer
Esophagus
Gastroenterology
Gastrointestinal cancer
Medical diagnosis
Medicine
Medicine & Public Health
Surgical Oncology
Thoracic Surgery
Throat surgery
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Summary:We report a case of esophagectomy after a primary esophageal gastrointestinal stromal tumor (GIST) was preoperatively treated with imatinib mesylate. A 71-year-old woman was diagnosed with an esophageal submucosal tumor by upper gastrointestinal endoscopy at her health checkup. The tumor was located at the lower thoracic esophagus immediately above the esophagogastric junction and measured 4.5 cm in size. It was diagnosed as GIST of the esophagus for reasons of its high susceptibility to imatinib mesylate. Preoperative treatment with imatinib was performed in an attempt to preserve the esophagus. Although the tumor size was decreased by 36% after the 6-month treatment, transhiatal esophagectomy was required for complete resection, and esophageal preservation could not be accomplished.
ISSN:1612-9059
1612-9067
DOI:10.1007/s10388-009-0217-9