Effects of Solanum undatum extract (SR‐T100) on photocarcinogenesis and photoaging of actinic keratosis

SR‐T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B‐induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR‐T100...

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Bibliographic Details
Published in:Journal of dermatology 2021-03, Vol.48 (3), p.344-352
Main Authors: Yang, Chao‐Chun, Wu, Chin‐Han, Wong, Tak‐Wah, Lai, Feng‐Jie, Wei, Kai‐Che, Lin, Tzu‐Kai, Lin, Chrang‐Shi, Zhao, Juemin, Xiang, Leihong, Kao, Chao‐Hsing, Wang, Ying‐Jan, Lan, Cheng‐Che Eric, Sheu, Hamm‐Ming
Format: Article
Language:English
Subjects:
actinic keratosis
Animals
Herbal medicine
Immunohistochemistry
Keratosis
Keratosis, Actinic - drug therapy
Mice
Papilloma
Pathogenesis
photoaging
photocarcinogenesis
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Remission
Skin
Skin Aging
Skin diseases
solamargine
Solanum
Solanum undatum
Topical medication
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Summary:SR‐T100 gel, containing solamargine extracted from Solanum undatum (synonym: Solanum incanum), had good therapeutic effects on actinic keratosis (AK) in human and ultraviolet B‐induced papilloma in mice. This study aimed to investigate the immunohistochemical changes in the human skin after SR‐T100 treatment. An immunohistochemical study was performed and the changes in photocarcinogenesis and photoaging markers after 16‐week SR‐T100 gel treatment were documented. SR‐T100 gel treatment for 16 weeks resulted in complete remission in nine AK lesions and partial remission in four AK lesions. SR‐T100 gel abolished the expression of mutant p53 and SOX2 and restored the expression of NOTCH1. Additionally, SR‐T100 gel improved wrinkling in human skin, while restoring the expression of lamin B1 and increasing synthesis of new elastic fibers. SR‐T100 gel had therapeutic effects on photocarcinogenesis and photoaging of photodamaged skin with AK.
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.15703