Outcomes of Cultivated Oral Mucosal Epithelial Transplantation in Eyes With Chronic Stevens-Johnson Syndrome Sequelae

To study the outcomes of cultivated oral mucosal epithelial transplantation (COMET) in eyes with chronic Stevens-Johnson syndrome (SJS) sequelae. Prospective interventional case series. Forty-five eyes of 41 patients with chronic SJS sequelae were recruited and evaluated from 2013 to 2017 in an inst...

Full description

Saved in:
Bibliographic Details
Published in:American journal of ophthalmology 2021-02, Vol.222, p.82-91
Main Authors: Venugopal, Renu, Nagpal, Ritu, Mohanty, Sujata, Sen, Seema, Kashyap, Seema, Agarwal, Tushar, Maharana, Prafulla K., Vajpayee, Rasik B., Sharma, Namrata
Format: Article
Language:English
Subjects:
Adult
Antibiotics
Biopsy
Cells, Cultured
Cornea
Corneal Transplantation - methods
Disease Progression
Drugs
Female
Genotype & phenotype
Humans
Male
Mouth Mucosa - transplantation
Patients
Prospective Studies
Skin diseases
Stem cells
Stevens-Johnson Syndrome - surgery
Treatment Outcome
Visual Acuity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To study the outcomes of cultivated oral mucosal epithelial transplantation (COMET) in eyes with chronic Stevens-Johnson syndrome (SJS) sequelae. Prospective interventional case series. Forty-five eyes of 41 patients with chronic SJS sequelae were recruited and evaluated from 2013 to 2017 in an institutional setting. All patients underwent COMET, with an aim of fornix reconstruction and visual rehabilitation. Change in corrected distance visual acuity (CDVA), severity scores of various ocular surface parameters, and the occurrence of complications were documented during a follow up period of 2 years. Attainment and maintenance of a stable ocular surface, as assessed by change in the ocular surface severity scores was the primary outcome measure, while change in CDVA was the secondary outcome measure. The mean preoperative CDVA was 2.7± 0.5 logMAR, which improved to 1.5± 0.7 logMAR and 1.49± 0.98 postoperatively, at 1- and 2-year follow-up visit. Overall, 82.2% eyes (37/45) had improvement in visual acuity, 13.3% (6/45) experienced no change, whereas 2 eyes (4.4%) had worsening of visual acuity. The total ocular surface severity scores improved from a mean preoperative value of 29.1± 9.7 to 18.7± 7.2 postoperatively, at 2-year follow-up. Two eyes developed persistent epithelial defects, with progression to corneal melting requiring keratoplasty. COMET allows successful and sustained restoration of ocular surface anatomy with functional improvement, in eyes with chronic sequelae of SJS.
ISSN:0002-9394
1879-1891
DOI:10.1016/j.ajo.2020.08.022