Fabrication and characterization of smart karaya gum/sodium alginate semi-IPN microbeads for controlled release of D-penicillamine drug

This article reports the fabrication of pH-sensitive microbeads from sodium alginate (SA) and modified karaya gum (KG). KG was modified by graft copolymerization using 2-hydroxyethyl methacrylate (2-HEMA) through in situ free radical polymerization reaction. The graft copolymer was blended with SA t...

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Bibliographic Details
Published in:Polymers & polymer composites 2021-03, Vol.29 (3), p.163-175
Main Authors: Reddy, O Sreekanth, Subha, MCS, Jithendra, T, Madhavi, C, Rao, K Chowdoji
Format: Article
Language:English
Subjects:
Acids
Biocompatibility
Controlled release
Copolymerization
Differential scanning calorimetry
Drug delivery systems
Efficiency
Fourier transforms
Free radical polymerization
Free radicals
Graft copolymers
Hydrogels
Infrared analysis
Kinetics
Nanoparticles
Nitrogen
Polyhydroxyethyl methacrylate
Polymer blends
Polymerization
Polyvinyl alcohol
Scanning electron microscopy
Sodium
Sodium alginate
Spectrum analysis
Thermogravimetric analysis
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Summary:This article reports the fabrication of pH-sensitive microbeads from sodium alginate (SA) and modified karaya gum (KG). KG was modified by graft copolymerization using 2-hydroxyethyl methacrylate (2-HEMA) through in situ free radical polymerization reaction. The graft copolymer was blended with SA to develop microbeads by a simple ionotropic gelation technique. The microbeads were characterized by Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, and scanning electron microscopy. The effect of %HEMA and polymer blend ratio on the swelling capacity was investigated. Drug release kinetics of the microbeads was investigated under both pH 7.4 and pH 1.2 at 37°C. The drug release kinetics was analyzed by evaluating the release data using different kinetic models.
ISSN:0967-3911
1478-2391
DOI:10.1177/0967391120904477