Preparation and Characterization of Two Different Liposomal Formulations with Bioactive Natural Extract for Multiple Applications

Liposomes continue to attract great interest due to their increased bioavailability in the body and because the substances encapsulated are protected while maintaining their effectiveness. The aim of this study is to obtain “giant” liposomes by lipid film hydration using a preparation formula with t...

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Bibliographic Details
Published in:Processes 2021-03, Vol.9 (3), p.432
Main Authors: Miere (Groza), Florina, Vicas, Simona Ioana, Timar, Adrian Vasile, Ganea, Mariana, Zdrinca, Mihaela, Cavalu, Simona, Fritea, Luminita, Vicas, Laura, Muresan, Mariana, Pallag, Annamaria, Dobjanschi, Luciana
Format: Article
Language:English
Subjects:
Antioxidants
Bioavailability
Encapsulation
Formulations
Lecithin
Light microscopy
Light scattering
Lipids
Liposomes
Medical research
Morphology
Optical microscopy
Pharmaceuticals
Phenols
Phosphatidylcholine
Phosphatidylserine
Phospholipids
Photon correlation spectroscopy
Size distribution
Stellaria media
Vaccines
Zeta potential
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Summary:Liposomes continue to attract great interest due to their increased bioavailability in the body and because the substances encapsulated are protected while maintaining their effectiveness. The aim of this study is to obtain “giant” liposomes by lipid film hydration using a preparation formula with two different phospholipids, phosphatidylcholine (PC) and phosphatidylserine (PS). Firstly, the macro- and microscopic characterization, total phenols content and antioxidant capacity of the plant Stellaria media (L.) Vill. were assessed. Then, Stellaria media (L.) Vill. extract was encapsulated in both formulations (PCE and PSE) and the liposomes were characterized according to their morphology, size distribution and Zeta potential using optical microscopy and dynamic light scattering. The encapsulation efficiency (EE%) was determined using the Folin–Ciocalteu method and the values of both formulations were compared. PC and PCE liposomes with a diameter between 712 and 1000 nm and PS and PSE liposomes with a diameter between 58 and 1000 nm were obtained. The values EE% of Stellaria media (L.) Vill. extract for PCE and PSE were 92.09% and 84.25%, respectively.
ISSN:2227-9717
2227-9717
DOI:10.3390/pr9030432