The emerging role of MEIS1 in cell proliferation and differentiation

Cell proliferation and differentiation are the foundation of reproduction and growth. Mistakes in these processes may affect cell survival, or cause cell cycle dysregulation, such as tumorigenesis, birth defects and degenerative diseases, or cell death. Myeloid ecotropic viral integration site 1 (ME...

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Published in:American Journal of Physiology: Cell Physiology 2021-03, Vol.320 (3), p.C264-C269
Main Authors: Jiang, Mingzhu, Xu, Shuang, Bai, Mi, Zhang, Aihua
Format: Article
Language:English
Subjects:
Animals
Carcinogenesis - genetics
Cardiomyocytes
Cell cycle
Cell death
Cell differentiation
Cell Differentiation - genetics
Cell fate
Cell growth
Cell proliferation
Cell Proliferation - genetics
Cell survival
Congenital defects
Degenerative diseases
Humans
Kinases
Leukemia
Myeloid Ecotropic Viral Integration Site 1 Protein - genetics
Myocytes, Cardiac - pathology
Neonates
Neoplasia
Therapeutic targets
Tumorigenesis
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container_title American Journal of Physiology: Cell Physiology
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creator Jiang, Mingzhu
Xu, Shuang
Bai, Mi
Zhang, Aihua
description Cell proliferation and differentiation are the foundation of reproduction and growth. Mistakes in these processes may affect cell survival, or cause cell cycle dysregulation, such as tumorigenesis, birth defects and degenerative diseases, or cell death. Myeloid ecotropic viral integration site 1 (MEIS1) was initially discovered in leukemic mice. Recent research identified MEIS1 as an important transcription factor that regulates cell proliferation and differentiation during cell fate commitment. MEIS1 has a pro-proliferative effect in leukemia cells; however, its overexpression in cardiomyocytes restrains neonatal and adult cardiomyocyte proliferation. In addition, MEIS1 has carcinogenic or tumor suppressive effects in different neoplasms. Thus, this uncertainty suggests that MEIS1 has a unique function in cell proliferation and differentiation. In this review, we summarize the primary findings of MEIS1 in regulating cell proliferation and differentiation. Correlations between MEIS1 and cell fate specification might suggest MEIS1 as a therapeutic target for diseases.
doi_str_mv 10.1152/ajpcell.00422.2020
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subjects Animals
Carcinogenesis - genetics
Cardiomyocytes
Cell cycle
Cell death
Cell differentiation
Cell Differentiation - genetics
Cell fate
Cell growth
Cell proliferation
Cell Proliferation - genetics
Cell survival
Congenital defects
Degenerative diseases
Humans
Kinases
Leukemia
Myeloid Ecotropic Viral Integration Site 1 Protein - genetics
Myocytes, Cardiac - pathology
Neonates
Neoplasia
Therapeutic targets
Tumorigenesis
title The emerging role of MEIS1 in cell proliferation and differentiation
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