Variations in IL-22, IL-27 and IL-35 serum levels in untreated and treated hepatitis C patients

BackgroundHepatitis C virus (HCV) is the leading cause of chronic liver diseases including hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. We aimed to assess serum levels of interleukin (IL)-22, IL-27 and IL-35 in patients with hepatitis C and healthy controls to investigate their possibl...

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Bibliographic Details
Published in:European cytokine network (Montrouge) 2020-12, Vol.31 (4), p.134-139
Main Authors: Taghinejad, Azam, Barani, Shaghik, Gholijani, Naser, Ghandehari, Farzad, Khansalar, Soolmaz, Asadipour, Morvarid, Davarpanah, Mohammadali, Fattahi, Mohammadreza, Kalantar, Kurosh
Format: Article
Language:English
Subjects:
Alanine
Alanine transaminase
Alkaline phosphatase
Antiviral agents
Aspartate transaminase
Chronic infection
Cirrhosis
Cytokines
Enzyme-linked immunosorbent assay
Enzymes
Fibrosis
Genotypes
Hepatitis C
Hepatocellular carcinoma
Interferon
Interleukin 22
Interleukin 27
Liver cirrhosis
Liver diseases
Peripheral blood
Serum levels
Transaminase
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Summary:BackgroundHepatitis C virus (HCV) is the leading cause of chronic liver diseases including hepatic fibrosis, cirrhosis, and hepatocellular carcinoma. We aimed to assess serum levels of interleukin (IL)-22, IL-27 and IL-35 in patients with hepatitis C and healthy controls to investigate their possible relationship with viral genotypes and liver enzyme levels.MethodA total of 30 newly diagnosed hepatitis C patients with no history of antiviral therapy and 30 healthy individuals participated in this study. Serum levels of IL-22, IL-27 and IL-35 were determined by ELISA in peripheral blood samples from patients prior to and following treament with pan-genotypic direct-acting anti-viral therapy. Serum levels of alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase (ALP) were measured to determine any possible association between hepatic enzymes and cytokine serum levels concentrations.ResultThe results show elevated serum levels of IL-35 in HCV-infected patients compared to treated cases and healthy controls, whereas there was no significant difference in IL-22 and IL-27 serum levels among the three groups. Additionally, the cytokine levels were not significantly correlated with certain genotypes and levels of liver enzymes.ConclusionOur findings indicate a potential role for IL-35 in chronic HCV infection and therapeutic management of patients with hepatitis C infection.
ISSN:1148-5493
1952-4005
DOI:10.1684/ecn.2020.0455