Loading…
Genomics-based approaches to identify and predict the health-promoting and safety activities of promising probiotic strains – A probiogenomics review
Over the past two decades, the clinical evidence supporting the beneficial effects of probiotics in consumer's health and wellness has increased. Hence, the food and pharmaceutical industries have encouraged the production of different probiotic foods and probiotic strains. So far, nearly all m...
Saved in:
Published in: | Trends in food science & technology 2021-02, Vol.108, p.148-163 |
---|---|
Main Authors: | , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Over the past two decades, the clinical evidence supporting the beneficial effects of probiotics in consumer's health and wellness has increased. Hence, the food and pharmaceutical industries have encouraged the production of different probiotic foods and probiotic strains. So far, nearly all marketed probiotics are from animal (dairy and human subjects) origin; however, other sources are increasingly being reported as promising reservoirs of new potential probiotics. In this last regard, before any possible application, probiotic candidates must be characterized by comprehensive trials.
This review aims to provide a contemporary perspective in the evaluation and characterization of probiotics under the “probiogenomics” context.
Typically, probiotic candidates are selected after several in vitro and in vivo trials aimed to determine their suitable resistance to physiological barriers such as simulated digestive conditions, sensitive inhibition of pathogens, adherence to mucus and hemolytic potential, among other properties. However, there is a need for additional research to further clarify the knowledge of their metabolic capabilities, key features of adaptation, and their physiological functions, including their safety and the molecular mechanism underlaying their functional activities. Thus, different genomics-based approaches, known as “probiogenomics”, have been successfully applied to facilitate the study of current probiotics and new potential candidates, including their health-promoting and safety properties.
[Display omitted]
•Traditional in vitro and in vivo assays are not always linked to probiotic efficacy and safety.•This manuscript presents an updated review on probiogenomics to characterize promising probiotic strains.•Genomic-based approaches may contribute to validate the role of probiotics in living organisms.•Probiogenomics could represent a valuable tool during the regulatory scenery for probiotics. |
---|---|
ISSN: | 0924-2244 1879-3053 |
DOI: | 10.1016/j.tifs.2020.12.017 |