Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without b...

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Bibliographic Details
Published in:New England Journal of Medicine 2021-04
Main Authors: Krammer, Florian, Srivastava, Komal, Alshammary, Hala, Amoako, Angela A, Awawda, Mahmoud H, Beach, Katherine F, Bermúdez-González, Maria C, Bielak, Dominika A, Carreño, Juan M, Chernet, Rachel L, Eaker, Lily Q, Ferreri, Emily D, Floda, Daniel L, Gleason, Charles R, Hamburger, Joshua Z, Jiang, Kaijun, Kleiner, Giulio, Jurczyszak, Denise, Matthews, Julia C, Mendez, Wanni A, Ismail Nabeel, Lubbertus C.F. Mulder, Raskin, Ariel J, Russo, Kayla T, Salimbangon, Ashley-Beathrese T, Saksena, Miti, Shin, Amber S, Singh, Gagandeep, Sominsky, Levy A, Stadlbauer, Daniel, Wajnberg, Ania, Simon, Viviana
Format: Article
Language:English
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Summary:Some persons who have recovered from Covid-19 have antibodies to the spike protein of SARS-CoV-2. In 43 such persons who had received a first mRNA vaccine dose, high levels of neutralizing antispike antibodies were produced — in many cases even higher than after a second dose in 67 persons without baseline antibodies to the virus. Systemic reactions were more common in those seropositive before vaccination.
DOI:10.1056/NEJMc2101667