5PSQ-141 Analysis of ceftaroline associated neutropenia

Background and importanceCeftaroline is a new fifth generation cephalosporin indicated for the treatment of severe pneumonia and skin and soft tissue infection, which is particularly effective against methicillin resistant Staphylococcus aureus (MRSA) and penicillin resistant strains of Streptococcu...

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Bibliographic Details
Published in:European journal of hospital pharmacy. Science and practice 2021-03, Vol.28 (Suppl 1), p.A126-A126
Main Authors: García Basas, L, Gago, Á Díaz, Sáez De La Fuente, J, Álvarez Díaz, AM
Format: Article
Language:English
Subjects:
Causality
Conflicts of interest
Intensive care
Neutropenia
Neutrophils
Pneumonia
Staphylococcus infections
Streptococcus infections
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Summary:Background and importanceCeftaroline is a new fifth generation cephalosporin indicated for the treatment of severe pneumonia and skin and soft tissue infection, which is particularly effective against methicillin resistant Staphylococcus aureus (MRSA) and penicillin resistant strains of Streptococcus pneumoniae. Some studies have found an association between prolonged use of ceftaroline and a higher incidence of neutropenia.Aim and objectivesTo study the incidence and causality of the onset of neutropenia associated with the use of ceftaroline in routine clinical practice.Material and methodsA retrospective observational study was conducted in a tertiary hospital between April 2017 and July 2020. Electronic records were used. Inclusion criteria were: adult patients treated with ceftaroline for >7 days. Exclusion criteria were: oncohaematological patients or those with a neutrophil count
ISSN:2047-9956
2047-9964
DOI:10.1136/ejhpharm-2021-eahpconf.260