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The influence of PM2.5 exposure on non-alcoholic fatty liver disease
Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter
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| Published in: | Life sciences (1973) 2021-04, Vol.270, p.119135, Article 119135 |
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| Main Authors: | , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c339t-812a3c809db1f6cc0a579cf1afebcddb96b4a82e9c4a7e1e70935e7788a543133 |
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| cites | cdi_FETCH-LOGICAL-c339t-812a3c809db1f6cc0a579cf1afebcddb96b4a82e9c4a7e1e70935e7788a543133 |
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| container_issue | |
| container_start_page | 119135 |
| container_title | Life sciences (1973) |
| container_volume | 270 |
| creator | Chen, Jiaxin Wu, Lei Yang, Guang Zhang, Cong Liu, Xiaofang Sun, Xiance Chen, Xin Wang, Ningning |
| description | Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter |
| doi_str_mv | 10.1016/j.lfs.2021.119135 |
| format | article |
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[Display omitted]</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/j.lfs.2021.119135</identifier><language>eng</language><publisher>New York: Elsevier Inc</publisher><subject>Endoplasmic reticulum ; Epithelium ; Exposure ; Fatty liver ; Fine particulate matter (PM2.5) ; Homeostasis ; Inflammation ; Intestine ; Liver ; Liver diseases ; miRNA ; Non-alcoholic fatty liver disease (NAFLD) ; Particulate matter ; Pathogenesis ; Phenotypes ; Ribonucleic acid ; RNA</subject><ispartof>Life sciences (1973), 2021-04, Vol.270, p.119135, Article 119135</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright Elsevier BV Apr 1, 2021</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c339t-812a3c809db1f6cc0a579cf1afebcddb96b4a82e9c4a7e1e70935e7788a543133</citedby><cites>FETCH-LOGICAL-c339t-812a3c809db1f6cc0a579cf1afebcddb96b4a82e9c4a7e1e70935e7788a543133</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Chen, Jiaxin</creatorcontrib><creatorcontrib>Wu, Lei</creatorcontrib><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Zhang, Cong</creatorcontrib><creatorcontrib>Liu, Xiaofang</creatorcontrib><creatorcontrib>Sun, Xiance</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Wang, Ningning</creatorcontrib><title>The influence of PM2.5 exposure on non-alcoholic fatty liver disease</title><title>Life sciences (1973)</title><description>Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter < 2.5 μm, PM2.5) and the incidence of non-alcoholic fatty liver disease (NAFLD). By referring to previous studies on the pathogenesis of NAFLD and PM2.5 exposure-induced metabolic damage, we summarized the possible mediating pathways through which PM2.5 exposure can cause the phenotype and progression of NAFLD. Crucially, PM2.5 exposure is considered to have an impact on the classic hypothesis “multiple hits” of NAFLD. In addition, we also concluded that exposure to PM2.5 can promote the development of NAFLD by destroying the intestinal epithelium and microbiotic homeostasis, triggering endoplasmic reticulum stress, inducing abnormal expression of specific microRNA or inflammatory factors.
[Display omitted]</description><subject>Endoplasmic reticulum</subject><subject>Epithelium</subject><subject>Exposure</subject><subject>Fatty liver</subject><subject>Fine particulate matter (PM2.5)</subject><subject>Homeostasis</subject><subject>Inflammation</subject><subject>Intestine</subject><subject>Liver</subject><subject>Liver diseases</subject><subject>miRNA</subject><subject>Non-alcoholic fatty liver disease (NAFLD)</subject><subject>Particulate matter</subject><subject>Pathogenesis</subject><subject>Phenotypes</subject><subject>Ribonucleic acid</subject><subject>RNA</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kE1LxDAQhoMouK7-AG8Bz62ZpOkHnmT9hBU9rOeQphM2pTZr0i7uv7dLPQsDA8P7zAwPIdfAUmCQ37ZpZ2PKGYcUoAIhT8gCyqJKWC7glCwY41kiOJPn5CLGljEmZSEW5GGzRep6243YG6Te0o83nkqKPzsfxzBNetr7PtGd8VvfOUOtHoYD7dweA21cRB3xkpxZ3UW8-utL8vn0uFm9JOv359fV_ToxQlRDUgLXwpSsamqwuTFMy6IyFrTF2jRNXeV1pkuOlcl0gYAFq4TEoihLLTMBQizJzbx3F_z3iHFQrR9DP51UXDLgORNTLQnMKRN8jAGt2gX3pcNBAVNHWapVkyx1lKVmWRNzNzM4vb93GFQ07mikcQHNoBrv_qF_ASPlcL4</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Chen, Jiaxin</creator><creator>Wu, Lei</creator><creator>Yang, Guang</creator><creator>Zhang, Cong</creator><creator>Liu, Xiaofang</creator><creator>Sun, Xiance</creator><creator>Chen, Xin</creator><creator>Wang, Ningning</creator><general>Elsevier Inc</general><general>Elsevier BV</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20210401</creationdate><title>The influence of PM2.5 exposure on non-alcoholic fatty liver disease</title><author>Chen, Jiaxin ; Wu, Lei ; Yang, Guang ; Zhang, Cong ; Liu, Xiaofang ; Sun, Xiance ; Chen, Xin ; Wang, Ningning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c339t-812a3c809db1f6cc0a579cf1afebcddb96b4a82e9c4a7e1e70935e7788a543133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Endoplasmic reticulum</topic><topic>Epithelium</topic><topic>Exposure</topic><topic>Fatty liver</topic><topic>Fine particulate matter (PM2.5)</topic><topic>Homeostasis</topic><topic>Inflammation</topic><topic>Intestine</topic><topic>Liver</topic><topic>Liver diseases</topic><topic>miRNA</topic><topic>Non-alcoholic fatty liver disease (NAFLD)</topic><topic>Particulate matter</topic><topic>Pathogenesis</topic><topic>Phenotypes</topic><topic>Ribonucleic acid</topic><topic>RNA</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Jiaxin</creatorcontrib><creatorcontrib>Wu, Lei</creatorcontrib><creatorcontrib>Yang, Guang</creatorcontrib><creatorcontrib>Zhang, Cong</creatorcontrib><creatorcontrib>Liu, Xiaofang</creatorcontrib><creatorcontrib>Sun, Xiance</creatorcontrib><creatorcontrib>Chen, Xin</creatorcontrib><creatorcontrib>Wang, Ningning</creatorcontrib><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Jiaxin</au><au>Wu, Lei</au><au>Yang, Guang</au><au>Zhang, Cong</au><au>Liu, Xiaofang</au><au>Sun, Xiance</au><au>Chen, Xin</au><au>Wang, Ningning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The influence of PM2.5 exposure on non-alcoholic fatty liver disease</atitle><jtitle>Life sciences (1973)</jtitle><date>2021-04-01</date><risdate>2021</risdate><volume>270</volume><spage>119135</spage><pages>119135-</pages><artnum>119135</artnum><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Emerging studies have pointed to a significant relationship between exposure to ambient fine particulate matter (aerodynamic diameter < 2.5 μm, PM2.5) and the incidence of non-alcoholic fatty liver disease (NAFLD). By referring to previous studies on the pathogenesis of NAFLD and PM2.5 exposure-induced metabolic damage, we summarized the possible mediating pathways through which PM2.5 exposure can cause the phenotype and progression of NAFLD. Crucially, PM2.5 exposure is considered to have an impact on the classic hypothesis “multiple hits” of NAFLD. In addition, we also concluded that exposure to PM2.5 can promote the development of NAFLD by destroying the intestinal epithelium and microbiotic homeostasis, triggering endoplasmic reticulum stress, inducing abnormal expression of specific microRNA or inflammatory factors.
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| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 2021-04, Vol.270, p.119135, Article 119135 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | ScienceDirect Journals |
| subjects | Endoplasmic reticulum Epithelium Exposure Fatty liver Fine particulate matter (PM2.5) Homeostasis Inflammation Intestine Liver Liver diseases miRNA Non-alcoholic fatty liver disease (NAFLD) Particulate matter Pathogenesis Phenotypes Ribonucleic acid RNA |
| title | The influence of PM2.5 exposure on non-alcoholic fatty liver disease |
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