Loading…

Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment

In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the soli...

Full description

Saved in:
Bibliographic Details
Published in:Key Engineering Materials 2020-08, Vol.856, p.237-244
Main Authors: Tuntarawongsa, Sarun, Phaechamud, Thawatchai, Mahadlek, Jongjan, Lertsuphotvanit, Nutdanai
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c2107-1d61138037d7e20bd10d0f8ebfb7bbd29843b2bbbc5d0ea391d511abfb7a28b33
container_end_page 244
container_issue
container_start_page 237
container_title Key Engineering Materials
container_volume 856
creator Tuntarawongsa, Sarun
Phaechamud, Thawatchai
Mahadlek, Jongjan
Lertsuphotvanit, Nutdanai
description In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the solid-like matrix after contact an aqueous environment by solvent exchange mechanism. This study aims to develop ISM which various concentrations of rosin (R) as matrix former dissolved in organic biocompatible and biodegradable solvents such as N-methyl-2-pyrrolidone, dimethyl sulfoxide and 2-pyrrolidone. Physicochemical characterization and matrix formation behavior owing to phase inversion of R ISM were evaluated including pH, density, viscosity, contact angles, surface tension, expelling force through a syringe, matrix formation behavior and morphological change. The density of all R ISM exhibited in the range of 1.03-1.11 g/cm3 and contact angles (9.04-44.13°) indicated a good wetting property. Higher R concentration decreased pH of ISM owing to increased amount of abietic and pimaric acid from R while the viscosity, contact angles and force for expelling a syringe were increased. The viscosity of R ISM in dimethyl sulfoxide was less than that in 2-pyrrolidone; thus, ISM using dimethyl sulfoxide as a solvent exhibited good injectability. ISM comprising R concentration > 30%w/w promoted a faster matrix growth in which the amount of occurred R matrix was enhanced with time and the rate of matrix formation was lower with time. Doxycycline Hyclate (Dx)-loaded 40%w/w ISM in dimethyl sulfoxide (Dx-DR) had pH of 3.70, density of 1.1084 ± 0.0005 g/ml, viscosity of 35.72 ± 0.00 cPs, contact angles of 26.87 ± 2.40°, surface tension of 37.11 ± 0.11 mN/m and expelling force of 23.98 ± 0.18 N. It showed the sustainable Dx release in simulated crevicular fluid and the efficient antimicrobial activity against Staphylococcus aureus and Porphyromonas gingivalis. Thus, this phase inversion induced R ISM using dimethyl sulfoxide as a solvent showed potential as an antimicrobial agent-loaded drug delivery system for periodontitis treatment.
doi_str_mv 10.4028/www.scientific.net/KEM.856.237
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_2501489949</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2501489949</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2107-1d61138037d7e20bd10d0f8ebfb7bbd29843b2bbbc5d0ea391d511abfb7a28b33</originalsourceid><addsrcrecordid>eNqNkFlLAzEUhYMLuP6HgODbjFk6M5kXccGlqFhs62vINhppk5pkrD74302p4KtPl3vP4dzDB8AxRuUAEXayXC7LqKxxyXZWlc6kk7urh5JVdUloswF2cV2Tom3aahPsUUSrBtcNIVtZQJgWLSP1DtiL8Q0hihmudsH36FVEA4fuw4RovSuGTvfKaPjko3X5Dsc29fDah7l1L_BBpGA_4TSulmcRrO8jfAwvwlkFL6xXfr4QycqZgWM_-8hFI-x8gCOTrdrn3slGOAlGpHkWD8B2J2bRHP7OfTC9vppc3hb3jzfDy_P7QhGMmgLrGmPKEG10YwiSGiONOmZkJxspNWnZgEoipVSVRkbQFusKY7GSBWGS0n1wtM5dBP_em5j4m--Dyy85qRAesLYdtNl1unap4GMMpuOLYOcifHGM-Io_z_z5H3-e-fPMn2f-PPPPAWfrgBSEi8mo178__4z4AWKql-c</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2501489949</pqid></control><display><type>article</type><title>Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment</title><source>Scientific.net Journals</source><creator>Tuntarawongsa, Sarun ; Phaechamud, Thawatchai ; Mahadlek, Jongjan ; Lertsuphotvanit, Nutdanai</creator><creatorcontrib>Tuntarawongsa, Sarun ; Phaechamud, Thawatchai ; Mahadlek, Jongjan ; Lertsuphotvanit, Nutdanai</creatorcontrib><description>In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the solid-like matrix after contact an aqueous environment by solvent exchange mechanism. This study aims to develop ISM which various concentrations of rosin (R) as matrix former dissolved in organic biocompatible and biodegradable solvents such as N-methyl-2-pyrrolidone, dimethyl sulfoxide and 2-pyrrolidone. Physicochemical characterization and matrix formation behavior owing to phase inversion of R ISM were evaluated including pH, density, viscosity, contact angles, surface tension, expelling force through a syringe, matrix formation behavior and morphological change. The density of all R ISM exhibited in the range of 1.03-1.11 g/cm3 and contact angles (9.04-44.13°) indicated a good wetting property. Higher R concentration decreased pH of ISM owing to increased amount of abietic and pimaric acid from R while the viscosity, contact angles and force for expelling a syringe were increased. The viscosity of R ISM in dimethyl sulfoxide was less than that in 2-pyrrolidone; thus, ISM using dimethyl sulfoxide as a solvent exhibited good injectability. ISM comprising R concentration &gt; 30%w/w promoted a faster matrix growth in which the amount of occurred R matrix was enhanced with time and the rate of matrix formation was lower with time. Doxycycline Hyclate (Dx)-loaded 40%w/w ISM in dimethyl sulfoxide (Dx-DR) had pH of 3.70, density of 1.1084 ± 0.0005 g/ml, viscosity of 35.72 ± 0.00 cPs, contact angles of 26.87 ± 2.40°, surface tension of 37.11 ± 0.11 mN/m and expelling force of 23.98 ± 0.18 N. It showed the sustainable Dx release in simulated crevicular fluid and the efficient antimicrobial activity against Staphylococcus aureus and Porphyromonas gingivalis. Thus, this phase inversion induced R ISM using dimethyl sulfoxide as a solvent showed potential as an antimicrobial agent-loaded drug delivery system for periodontitis treatment.</description><identifier>ISSN: 1013-9826</identifier><identifier>ISSN: 1662-9795</identifier><identifier>ISBN: 3035716722</identifier><identifier>ISBN: 9783035716726</identifier><identifier>EISSN: 1662-9795</identifier><identifier>DOI: 10.4028/www.scientific.net/KEM.856.237</identifier><language>eng</language><publisher>Zurich: Trans Tech Publications Ltd</publisher><subject>Antiinfectives and antibacterials ; Antimicrobial agents ; Aqueous environments ; Biocompatibility ; Biodegradability ; Contact angle ; Density ; Dimethyl sulfoxide ; Drug delivery systems ; Gum disease ; Injectability ; Phase inversion ; Phase shift ; Phase transitions ; Rosin ; Solvents ; Sulfoxides ; Surface tension ; Syringes ; Viscosity ; Wetting</subject><ispartof>Key Engineering Materials, 2020-08, Vol.856, p.237-244</ispartof><rights>2020 Trans Tech Publications Ltd</rights><rights>Copyright Trans Tech Publications Ltd. Aug 2020</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2107-1d61138037d7e20bd10d0f8ebfb7bbd29843b2bbbc5d0ea391d511abfb7a28b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttps://www.scientific.net/Image/TitleCover/6036?width=600</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Tuntarawongsa, Sarun</creatorcontrib><creatorcontrib>Phaechamud, Thawatchai</creatorcontrib><creatorcontrib>Mahadlek, Jongjan</creatorcontrib><creatorcontrib>Lertsuphotvanit, Nutdanai</creatorcontrib><title>Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment</title><title>Key Engineering Materials</title><description>In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the solid-like matrix after contact an aqueous environment by solvent exchange mechanism. This study aims to develop ISM which various concentrations of rosin (R) as matrix former dissolved in organic biocompatible and biodegradable solvents such as N-methyl-2-pyrrolidone, dimethyl sulfoxide and 2-pyrrolidone. Physicochemical characterization and matrix formation behavior owing to phase inversion of R ISM were evaluated including pH, density, viscosity, contact angles, surface tension, expelling force through a syringe, matrix formation behavior and morphological change. The density of all R ISM exhibited in the range of 1.03-1.11 g/cm3 and contact angles (9.04-44.13°) indicated a good wetting property. Higher R concentration decreased pH of ISM owing to increased amount of abietic and pimaric acid from R while the viscosity, contact angles and force for expelling a syringe were increased. The viscosity of R ISM in dimethyl sulfoxide was less than that in 2-pyrrolidone; thus, ISM using dimethyl sulfoxide as a solvent exhibited good injectability. ISM comprising R concentration &gt; 30%w/w promoted a faster matrix growth in which the amount of occurred R matrix was enhanced with time and the rate of matrix formation was lower with time. Doxycycline Hyclate (Dx)-loaded 40%w/w ISM in dimethyl sulfoxide (Dx-DR) had pH of 3.70, density of 1.1084 ± 0.0005 g/ml, viscosity of 35.72 ± 0.00 cPs, contact angles of 26.87 ± 2.40°, surface tension of 37.11 ± 0.11 mN/m and expelling force of 23.98 ± 0.18 N. It showed the sustainable Dx release in simulated crevicular fluid and the efficient antimicrobial activity against Staphylococcus aureus and Porphyromonas gingivalis. Thus, this phase inversion induced R ISM using dimethyl sulfoxide as a solvent showed potential as an antimicrobial agent-loaded drug delivery system for periodontitis treatment.</description><subject>Antiinfectives and antibacterials</subject><subject>Antimicrobial agents</subject><subject>Aqueous environments</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Contact angle</subject><subject>Density</subject><subject>Dimethyl sulfoxide</subject><subject>Drug delivery systems</subject><subject>Gum disease</subject><subject>Injectability</subject><subject>Phase inversion</subject><subject>Phase shift</subject><subject>Phase transitions</subject><subject>Rosin</subject><subject>Solvents</subject><subject>Sulfoxides</subject><subject>Surface tension</subject><subject>Syringes</subject><subject>Viscosity</subject><subject>Wetting</subject><issn>1013-9826</issn><issn>1662-9795</issn><issn>1662-9795</issn><isbn>3035716722</isbn><isbn>9783035716726</isbn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><recordid>eNqNkFlLAzEUhYMLuP6HgODbjFk6M5kXccGlqFhs62vINhppk5pkrD74302p4KtPl3vP4dzDB8AxRuUAEXayXC7LqKxxyXZWlc6kk7urh5JVdUloswF2cV2Tom3aahPsUUSrBtcNIVtZQJgWLSP1DtiL8Q0hihmudsH36FVEA4fuw4RovSuGTvfKaPjko3X5Dsc29fDah7l1L_BBpGA_4TSulmcRrO8jfAwvwlkFL6xXfr4QycqZgWM_-8hFI-x8gCOTrdrn3slGOAlGpHkWD8B2J2bRHP7OfTC9vppc3hb3jzfDy_P7QhGMmgLrGmPKEG10YwiSGiONOmZkJxspNWnZgEoipVSVRkbQFusKY7GSBWGS0n1wtM5dBP_em5j4m--Dyy85qRAesLYdtNl1unap4GMMpuOLYOcifHGM-Io_z_z5H3-e-fPMn2f-PPPPAWfrgBSEi8mo178__4z4AWKql-c</recordid><startdate>20200803</startdate><enddate>20200803</enddate><creator>Tuntarawongsa, Sarun</creator><creator>Phaechamud, Thawatchai</creator><creator>Mahadlek, Jongjan</creator><creator>Lertsuphotvanit, Nutdanai</creator><general>Trans Tech Publications Ltd</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>F28</scope><scope>FR3</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>L6V</scope><scope>M7S</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope></search><sort><creationdate>20200803</creationdate><title>Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment</title><author>Tuntarawongsa, Sarun ; Phaechamud, Thawatchai ; Mahadlek, Jongjan ; Lertsuphotvanit, Nutdanai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2107-1d61138037d7e20bd10d0f8ebfb7bbd29843b2bbbc5d0ea391d511abfb7a28b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antiinfectives and antibacterials</topic><topic>Antimicrobial agents</topic><topic>Aqueous environments</topic><topic>Biocompatibility</topic><topic>Biodegradability</topic><topic>Contact angle</topic><topic>Density</topic><topic>Dimethyl sulfoxide</topic><topic>Drug delivery systems</topic><topic>Gum disease</topic><topic>Injectability</topic><topic>Phase inversion</topic><topic>Phase shift</topic><topic>Phase transitions</topic><topic>Rosin</topic><topic>Solvents</topic><topic>Sulfoxides</topic><topic>Surface tension</topic><topic>Syringes</topic><topic>Viscosity</topic><topic>Wetting</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuntarawongsa, Sarun</creatorcontrib><creatorcontrib>Phaechamud, Thawatchai</creatorcontrib><creatorcontrib>Mahadlek, Jongjan</creatorcontrib><creatorcontrib>Lertsuphotvanit, Nutdanai</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>ANTE: Abstracts in New Technology &amp; Engineering</collection><collection>Engineering Research Database</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>ProQuest Engineering Collection</collection><collection>Engineering Database</collection><collection>Materials Science Collection</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><jtitle>Key Engineering Materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuntarawongsa, Sarun</au><au>Phaechamud, Thawatchai</au><au>Mahadlek, Jongjan</au><au>Lertsuphotvanit, Nutdanai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment</atitle><jtitle>Key Engineering Materials</jtitle><date>2020-08-03</date><risdate>2020</risdate><volume>856</volume><spage>237</spage><epage>244</epage><pages>237-244</pages><issn>1013-9826</issn><issn>1662-9795</issn><eissn>1662-9795</eissn><isbn>3035716722</isbn><isbn>9783035716726</isbn><abstract>In situ forming matrix (ISM) is an injectable drug delivery system containing a drug-loaded polymeric solution. It was applied for local drug administration such as into a periodontal pocket for periodontitis treatment with an antimicrobial agent. ISM can transform with phase inversion into the solid-like matrix after contact an aqueous environment by solvent exchange mechanism. This study aims to develop ISM which various concentrations of rosin (R) as matrix former dissolved in organic biocompatible and biodegradable solvents such as N-methyl-2-pyrrolidone, dimethyl sulfoxide and 2-pyrrolidone. Physicochemical characterization and matrix formation behavior owing to phase inversion of R ISM were evaluated including pH, density, viscosity, contact angles, surface tension, expelling force through a syringe, matrix formation behavior and morphological change. The density of all R ISM exhibited in the range of 1.03-1.11 g/cm3 and contact angles (9.04-44.13°) indicated a good wetting property. Higher R concentration decreased pH of ISM owing to increased amount of abietic and pimaric acid from R while the viscosity, contact angles and force for expelling a syringe were increased. The viscosity of R ISM in dimethyl sulfoxide was less than that in 2-pyrrolidone; thus, ISM using dimethyl sulfoxide as a solvent exhibited good injectability. ISM comprising R concentration &gt; 30%w/w promoted a faster matrix growth in which the amount of occurred R matrix was enhanced with time and the rate of matrix formation was lower with time. Doxycycline Hyclate (Dx)-loaded 40%w/w ISM in dimethyl sulfoxide (Dx-DR) had pH of 3.70, density of 1.1084 ± 0.0005 g/ml, viscosity of 35.72 ± 0.00 cPs, contact angles of 26.87 ± 2.40°, surface tension of 37.11 ± 0.11 mN/m and expelling force of 23.98 ± 0.18 N. It showed the sustainable Dx release in simulated crevicular fluid and the efficient antimicrobial activity against Staphylococcus aureus and Porphyromonas gingivalis. Thus, this phase inversion induced R ISM using dimethyl sulfoxide as a solvent showed potential as an antimicrobial agent-loaded drug delivery system for periodontitis treatment.</abstract><cop>Zurich</cop><pub>Trans Tech Publications Ltd</pub><doi>10.4028/www.scientific.net/KEM.856.237</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1013-9826
ispartof Key Engineering Materials, 2020-08, Vol.856, p.237-244
issn 1013-9826
1662-9795
1662-9795
language eng
recordid cdi_proquest_journals_2501489949
source Scientific.net Journals
subjects Antiinfectives and antibacterials
Antimicrobial agents
Aqueous environments
Biocompatibility
Biodegradability
Contact angle
Density
Dimethyl sulfoxide
Drug delivery systems
Gum disease
Injectability
Phase inversion
Phase shift
Phase transitions
Rosin
Solvents
Sulfoxides
Surface tension
Syringes
Viscosity
Wetting
title Phase Inversion-Induced Rosin In Situ Forming Matrix Using Various Organic Biocompatible Solvents for Periodontitis Treatment
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A59%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Phase%20Inversion-Induced%20Rosin%20In%20Situ%20Forming%20Matrix%20Using%20Various%20Organic%20Biocompatible%20Solvents%20for%20Periodontitis%20Treatment&rft.jtitle=Key%20Engineering%20Materials&rft.au=Tuntarawongsa,%20Sarun&rft.date=2020-08-03&rft.volume=856&rft.spage=237&rft.epage=244&rft.pages=237-244&rft.issn=1013-9826&rft.eissn=1662-9795&rft.isbn=3035716722&rft.isbn_list=9783035716726&rft_id=info:doi/10.4028/www.scientific.net/KEM.856.237&rft_dat=%3Cproquest_cross%3E2501489949%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c2107-1d61138037d7e20bd10d0f8ebfb7bbd29843b2bbbc5d0ea391d511abfb7a28b33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2501489949&rft_id=info:pmid/&rfr_iscdi=true