Regioselective Access to 3‐Ethylideneflavanones via Rhodium(I)‐Catalyzed 1,3‐Enyne Hydroacylation/Annulation Cascades

The highly efficient synthesis of 3‐ethylideneflavanones through sequential rhodium(I)‐catalyzed hydroacylation of terminal aryl‐substituted 1,3‐enynes with chelating aldehydes and annulation is described. This straightforward protocol highlights an unprecedented C3‐regioselective hydroacylation of...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2021-03, Vol.363 (6), p.1722-1726
Main Authors: Chang, Zhi‐Xin, Li, Fu‐Rong, Xia, Chengcai, Li, Fei, Li, Hong‐Shuang
Format: Article
Language:English
Subjects:
1,3-Enyne
3-Ethylideneflavanone
Aldehydes
Chelation
Chemical reactions
Functional groups
Hydroacylation
Organic chemistry
Regioselective synthesis
Regioselectivity
Rhodium
Rhodium catalysis
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Summary:The highly efficient synthesis of 3‐ethylideneflavanones through sequential rhodium(I)‐catalyzed hydroacylation of terminal aryl‐substituted 1,3‐enynes with chelating aldehydes and annulation is described. This straightforward protocol highlights an unprecedented C3‐regioselective hydroacylation of 1,3‐enynes, excellent functional group compatibility, and complete atom economy.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.202001565