Evaluation of feeding immunoglobulin-Y to Holstein feeder cattle for the control of liver abscesses & reduction of macrolide-resistant bacteria dissemination

• Published in: Journal of animal science 2020-11, Vol.98, p.10-10
• Main Authors: Stotz, Miranda K, Murillo, Diego Casas, Henry, Darren D, Crossland, Whitney L
• Format: Article
• Language: English
• Subjects: Abscesses; Antibiotic resistance; Antibiotics; Bacteria; Beef cattle; Carcasses; Cattle; Continuity (mathematics); Diet; Enterococcus; Erythromycin; Feedlots; Feeds; Food additives; Immunoglobulins; Liver; Muscles; Quality; Tylosin
• ISSN: 0021-8812; 1525-3163

Despite the regular use of macrolide-antibiotics in the diets of feedlot cattle, liver abscesses persist representing a financial burden to both pre- and post-mortem sectors of the beef industry. Alternative strategies, which simultaneously address liver infections and reduce the dissemination of antibiotic-resistant bacteria, are needed. An immunoglobulin-Y (IGY) product, developed to target Fusobacterium necrophorum and Trueperella pyogenes, was evaluated for the control of liver abscesses and its effect on macrolide-resistant Enterococcus growth from feces. Sixty-four Holstein steers (Initial BW= 384± 13.5kg) consuming a finishing diet (90% concentrate) for 188 days (Final BW= 660± 42 kg) were used in a completely randomized design where steer was experimental unit and treatments included: TYL (Tylosin phosphate fed at 90mg/hd/day; n = 32) or IGY (fed at 2.5g/hd/day; n= 32). Feed intake was recorded daily and BW was recorded every 28 days until slaughter. After 150 d on treatment fecal samples were randomly obtained from each treatment group four times (n = 40) and cultured on bileesculine agar enriched with 8 µg/mL of erythromycin. Continuous variables of feedlot growth performance, carcass data and bacterial growth were analyzed using the MIXED procedure of SAS with the fixed effect of treatment and random effects of steer or sampling day, respectively. Ordinal carcass data were analyzed using the FREQ procedure of SAS observing the CochranMantel-Haenszel value. Treatment did not affect DMI (P= 0.21), ADG (P = 0.50) or G:F (P = 0.36). Treatment neither affected hot carcass weight (P = 0.37) nor longissimus muscle area (P = 0.25). However, TYL resulted in greater back fat thickness than IGY (0.32 vs. 0.23 in.; P < 0.02) and consequently greater numerical yield grade (P < 0.02). Quality grade was not affected by treatment (P = 0.65). No treatment difference was observed for liver abscesses prevalence (TYL=63% vs. IGY=52%; P = 0.40) or severity (P = 0.23). There was a greater proportion of erythromycin-resistant Enterococcus growth for TYL than IGY (42.6 vs. 21.9%; P < 0.04). Specifically formulated IGY feed additives may be viable alternatives to antibiotics in feedlot cattle diets.