A novel approach to understanding CoViD-19: exploring the interplay of SARS-CoV-2 and CTL response

• Published in: arXiv.org 2023-06
• Main Author: João Paulo Simões Maurício de Carvalho
• Format: Article
• Language: English
• Subjects: Coronaviruses; COVID-19; Cytotoxicity; Fatalities; Immune system; Lymphocytes; Mathematical models; Organs; Respiratory diseases; Respiratory system; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Viral diseases
• ISSN: 2331-8422

Facing a global challenge with over 6.9 million fatalities, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of CoViD-19, demands novel and comprehensive approaches to understand its complex dynamics. This paper introduces a non-integer order model, capturing the intricate interplay between SARS-CoV-2 and the host's cytotoxic T lymphocytes (CTLs) response. Our work reveals a unique parameter space, in which an endemic state of SARS-CoV-2 and a CTL response-free equilibrium can coexist -- a crucial finding in our quest to decipher this pervasive virus. We further explore the basic reproduction number, assessing how different model parameters can potentially inhibit or fuel the infection's progression. Through extensive numerical simulations, we scrutinize the impact of varying the order of the fractional derivative and employing diverse CTL proliferation functions. This study significantly enriches our understanding of CoViD-19 immunopathology, offering invaluable insights that could guide future research and therapeutic strategies.