Design and application of a self-pumping microfluidic staggered herringbone mixer

The rapid mixing of reagents is critical to a wide range of chemical and biological reactions but is difficult to implement in microfluidic devices, particularly in capillary action/passive pumping devices or in point-of-need environments. Here, we develop a self-pumping asymmetric staggered herring...

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Bibliographic Details
Published in:Microfluidics and nanofluidics 2021-04, Vol.25 (4), Article 31
Main Authors: Channon, Robert B., Menger, Ruth F., Wang, Wei, Carrão, Daniel B., Vallabhuneni, Sravanthi, Kota, Arun K., Henry, Charles S.
Format: Article
Language:English
Subjects:
Ablation
Aerospace engineering
Analytical Chemistry
Bio-assays
Bioengineering
Biomedical engineering
Biomedical Engineering and Bioengineering
Capillarity
Chemical reactions
Design
Engineering
Engineering Fluid Dynamics
Ethanol
Flow rates
Flow velocity
Grooves
Lab-on-a-chip
Lasers
Microfluidic devices
Nanotechnology and Microengineering
Nickel
o-Dianisidine
Peroxidase
Pumping
Rapid flow
Reagents
Research Paper
Solvents
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Summary:The rapid mixing of reagents is critical to a wide range of chemical and biological reactions but is difficult to implement in microfluidic devices, particularly in capillary action/passive pumping devices or in point-of-need environments. Here, we develop a self-pumping asymmetric staggered herringbone mixer made from only laser-ablated glass and tape. This lab-on-a-chip platform is capable of rapid flow (0.14 mL min −1 , 1 cm s −1 ) and fast mixing (
ISSN:1613-4982
1613-4990
DOI:10.1007/s10404-021-02426-x