Synthesis and Acaricidal Activity of Aryl-Spirobutyrolactone Derivatives against Spider Mites under Greenhouse and Field Conditions

Propesticides play an important role in modern agrochemicals research and development. In the controlling of harmful insects and mites in agriculture, propesticide strategy offers a unique and modern approach to acaricide development. In this study, a series of aryl-spirobutyrolactone pharmacophore...

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Bibliographic Details
Published in:Russian journal of bioorganic chemistry 2021-01, Vol.47 (1), p.221-229
Main Authors: Zhong, L. K., Yuan, J., Liu, X. H., Xu, T. M., Tan, C. X.
Format: Article
Language:English
Subjects:
Agrochemicals
Alkylation
Aromatic compounds
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Insects
Life Sciences
NMR
Nuclear magnetic resonance
Organic Chemistry
R&D
Research & development
Toxicity testing
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Summary:Propesticides play an important role in modern agrochemicals research and development. In the controlling of harmful insects and mites in agriculture, propesticide strategy offers a unique and modern approach to acaricide development. In this study, a series of aryl-spirobutyrolactone pharmacophore based alkylated compounds were synthesized and characterized by 1 H NMR and ESI-MS. All of this compounds exhibited excellent acaricidal activities against Tetranychus cinnabarinus at 2.5 mg/L in greenhouse test, and some of them showed better activity than spirodiclofen against eggs of T. cinnabarinus at 0.625 mg/L. In the field trials, compounds ( Vc ), ( Ve ) and ( Vf ) were evaluated against Panonychus ulmi and Panonychus citri at three different concentrations. The results showed that compounds ( Ve ) and ( Vf ) have the potential to develop into new proacaricide with further test and toxicity evaluation.
ISSN:1068-1620
1608-330X
DOI:10.1134/S1068162021010295