A ratiometric electrochemiluminescent cytosensor based on polyaniline hydrogel electrodes in spatially separated electrochemiluminescent systems

Here, we proposed a ratiometric electrochemiluminescent (ECL) strategy in spatially multiplied ECL systems. By the specific recognition of hyaluronic acid with proteoglycan CD44 and epidermal growth factor with epidermal growth factor receptor on the cell surface, the cells were labelled with potent...

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Bibliographic Details
Published in:Analyst (London) 2021-03, Vol.146 (6), p.1835-1838
Main Authors: Liu, Gen, Chen, Zixuan, Jin, Bao-Kang, Jiang, Li-Ping
Format: Article
Language:English
Subjects:
Aniline Compounds
Biosensing Techniques
Carbon nitride
Electrochemiluminescence
Electrodes
Epidermal growth factor
Growth factors
Hyaluronic acid
Hydrogels
Luminescent Measurements
Polyanilines
Proteoglycans
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Summary:Here, we proposed a ratiometric electrochemiluminescent (ECL) strategy in spatially multiplied ECL systems. By the specific recognition of hyaluronic acid with proteoglycan CD44 and epidermal growth factor with epidermal growth factor receptor on the cell surface, the cells were labelled with potential-resolved ECL probes, namely Ru(bpy) 3 2+ and g-C 3 N 4 , respectively. The as-proposed cytosensor provides a multichannel ECL protocol to improve the throughput, which may push the application of ECL for the cellular immunoanalysis. A three-channel ratiometric ECL platform for MCF-7 cells detection using potential-resolved ECL probes.
ISSN:0003-2654
1364-5528
DOI:10.1039/d0an02408b