0537 DURATION OF CPAP USAGE AND DAILY FUNCTIONING

• Published in: Sleep (New York, N.Y.) N.Y.), 2017-04, Vol.40 (suppl_1), p.A200-A200
• Main Authors: Izci Balserak, B, Maislin, G, Kuna, S, Gurubhagavatula, I, Weaver, T
• Format: Article
• Language: English
• Subjects: Continuous positive airway pressure
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleepj/zsx050.536

Abstract Introduction: Evidence suggests that, to maintain treatment effects, CPAP needs to be used every night. However it is not known the nightly duration of CPAP use required to normalize functioning. This study aimed to evaluate dose-response relationship between improvement of daily functioning and CPAP usage. Methods: This study included 109 patients with mild to moderate OSA who used active CPAP in previously-performed RCT. Five patients are excluded from the study due to technical failures in measuring CPAP compliance. Patients used 8 weeks of active nasal CPAP, and completed the Functional Outcomes of Sleep Questionnaire (FOSQ) at baseline and after 8 weeks of CPAP treatment. To examine the relationship between CPAP duration and outcome, a piecewise regression analysis was performed. This analysis estimates separate dose-response relationships of participants with mean CPAP use below a specified threshold (first segment) and above a specified threshold (second segment). Results: Changes from baseline to 8-week in FOSQ total score by CPAP use was positive for the 17 subjects with the lowest CPAP use category. The mean(SD) improvement was 1.05(2.19) with p=0.06. However, the mean changes were nearly equal to zero for those with mean use for the 37 subjects with >2-=4 to =5 to =6 to =7 hrs, the mean (SD) improvement was 3.25 (3.257) with p=0.01. Expected change is positive with at least 3.7 hours use. The predicted improvement does not reach the mean improvement of 0.90 points until mean CPAP use reaches at least 4.7 hours. Conclusion: Our analyses suggest that a greater percentage of patients will achieve normal functioning with longer nightly CPAP duration. Support (If Any): R01HL076101.