0436 THE ASSOCIATION BETWEEN GESTATIONAL DIABETES MELLITUS AND SLEEP-DISORDERED BREATHING

• Published in: Sleep (New York, N.Y.) N.Y.), 2017-04, Vol.40 (suppl_1), p.A162-A162
• Main Authors: Izci Balserak, B, Pien, G, Pack, A, Mastrogiannis, D, Carley, D, Prasad, B, Steffen, A, Weaver, T
• Format: Article
• Language: English
• Subjects: Gestational diabetes; Pregnancy; Sleep disorders; Variables
• ISSN: 0161-8105; 1550-9109
• DOI: 10.1093/sleepj/zsx050.435

Abstract Introduction: An estimated 4.6–9.2% of pregnancies are complicated by GDM which is an important public concern due to its association with maternal and fetal complications. Data on sleep disturbances including sleep-disordered breathing (SDB) in GDM is controversial. Evidence investigating the associations between GDM and SDB using objective measures is limited. This study aimed to determine if SDB is associated with an increased risk of GDM. Methods: Women with GDM (n=38) and healthy pregnant women (n=33) matched for race, maternal age (32.2 ± 3.9 yrs vs 31.8 ± 4.3 yrs, respectively) and parity underwent a full lab-polysomnography after being screened for GDM (24–36 wks pregnancy). They also completed questionnaires including Sleep Apnea Symptom Score (SASS) from the Multivariable Apnea Prediction index. Bivariate and multivariable logistic regression analyses were performed to determine the clinical characteristics that were significantly associated with GDM. Using GDM diagnosis as the dependent variable, sleep and demographic variables having a P3% and >4% per hour), were significantly linked with GDM diagnosis (OR 1.20; 95% CI, 1.02–1.41 vs OR 1.40; 95% CI, 1.02–1.92, respectively), adjusting the same variables mentioned above. Conclusion: This study indicates that PSG-confirmed OSA diagnosis and oxygen desaturations were associated with the occurrence of GDM. The clinical significance of these associations needs to be investigated in a future study with larger sample size. Support (If Any): R00NR013187.