New dihydrochromene and xanthone derivatives from Lisotrigona furva propolis

A new dihydrochromene derivative, named lisofurvin (1) and a xanthone, named dihydrobrasixanthone B (2) together with twenty one known compounds (3−23) were isolated from propolis of the stingless bee Lisotrigona furva. Their chemical structures were determined by means of spectroscopic methods incl...

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Bibliographic Details
Published in:Fitoterapia 2021-03, Vol.149 (NA), p.104821, Article 104821
Main Authors: Oanh, Vu Thi Kim, Thoa, Ha Thi, Hang, Nguyen Thi Minh, Phuong, Diep Thi Lan, Lien, Nguyen Thi Phuong, Popova, Milena, Trusheva, Boryana, Bankova, Vassya, Le, Thanh Nguyen
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Antimicrobial
Antimicrobial activity
Biotechnology
Cancer
Cratoxylum cochinchinense
Cytotoxicity
Lisotrigona furva
NMR
Nuclear magnetic resonance
Propolis
Tumor cell lines
Xanthones
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Summary:A new dihydrochromene derivative, named lisofurvin (1) and a xanthone, named dihydrobrasixanthone B (2) together with twenty one known compounds (3−23) were isolated from propolis of the stingless bee Lisotrigona furva. Their chemical structures were determined by means of spectroscopic methods including 1D and 2D NMR, and MS. The chemical constituents are predominantly geranyl(oxy) xanthones and Cratoxylum cochinchinense was suggested as a resin source, besides two other plants Mangifera indica and dammar trees (Dipterocarpaceae). Compound 1 showed significant cytotoxic activity against KB, HepG-2, and Lu-1 cancer cell lines with IC50 values range from 12.63 to 15.17 μg/mL. Several isolated compounds were active against one to four tested cancer cell lines. In addition, among the isolated compounds, α-mangostin (15) displayed the strongest antimicrobial activity against three Gram (+) strains, P. aeruginosa, and C. albicans with MIC values ranging between 1 and 2 μg/mL. Compound 22 showed good activity against three Gram (+) strains and C. albicans. [Display omitted]
ISSN:0367-326X
1873-6971
DOI:10.1016/j.fitote.2020.104821