Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy

Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for...

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Bibliographic Details
Published in:Nano research 2019-06, Vol.12 (6), p.1307-1312
Main Authors: Zhu, Wenjun, Yang, Yu, Jin, Qiutong, Chao, Yu, Tian, Longlong, Liu, Jingjing, Dong, Ziliang, Liu, Zhuang
Format: Article
Language:English
Subjects:
Anticancer properties
Antitumor activity
Atomic/Molecular Structure and Spectra
Biodegradability
Biodegradation
Biomedicine
Biotechnology
Cancer
Cancer therapies
Chemistry and Materials Science
Chemotherapy
Computed tomography
Condensed Matter Physics
Diagnostic systems
Homing
Intravenous administration
Materials Science
Medical imaging
Metal-organic frameworks
Nanotechnology
Oxygen production
Photodynamic therapy
Photon emission
Polyethylene glycol
Porphyrins
Radioisotopes
Research Article
Single photon emission computed tomography
Singlet oxygen
Tomography
Two dimensional materials
Zinc
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Summary:Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn 2+ and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope, 99m Tc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic in vivo antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-018-2242-2