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Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy
Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for...
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| Published in: | Nano research 2019-06, Vol.12 (6), p.1307-1312 |
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| Main Authors: | , , , , , , , |
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| cites | cdi_FETCH-LOGICAL-c344t-1740dc5ca73d9c37433f5dc1eaa986caf7a164431f2cd44bf1c0b34e8382ae473 |
| container_end_page | 1312 |
| container_issue | 6 |
| container_start_page | 1307 |
| container_title | Nano research |
| container_volume | 12 |
| creator | Zhu, Wenjun Yang, Yu Jin, Qiutong Chao, Yu Tian, Longlong Liu, Jingjing Dong, Ziliang Liu, Zhuang |
| description | Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn
2+
and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope,
99m
Tc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic
in vivo
antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications. |
| doi_str_mv | 10.1007/s12274-018-2242-2 |
| format | article |
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2+
and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope,
99m
Tc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic
in vivo
antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications.</description><identifier>ISSN: 1998-0124</identifier><identifier>EISSN: 1998-0000</identifier><identifier>DOI: 10.1007/s12274-018-2242-2</identifier><language>eng</language><publisher>Beijing: Tsinghua University Press</publisher><subject>Anticancer properties ; Antitumor activity ; Atomic/Molecular Structure and Spectra ; Biodegradability ; Biodegradation ; Biomedicine ; Biotechnology ; Cancer ; Cancer therapies ; Chemistry and Materials Science ; Chemotherapy ; Computed tomography ; Condensed Matter Physics ; Diagnostic systems ; Homing ; Intravenous administration ; Materials Science ; Medical imaging ; Metal-organic frameworks ; Nanotechnology ; Oxygen production ; Photodynamic therapy ; Photon emission ; Polyethylene glycol ; Porphyrins ; Radioisotopes ; Research Article ; Single photon emission computed tomography ; Singlet oxygen ; Tomography ; Two dimensional materials ; Zinc</subject><ispartof>Nano research, 2019-06, Vol.12 (6), p.1307-1312</ispartof><rights>Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018</rights><rights>Nano Research is a copyright of Springer, (2018). All Rights Reserved.</rights><rights>Tsinghua University Press and Springer-Verlag GmbH Germany, part of Springer Nature 2018.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c344t-1740dc5ca73d9c37433f5dc1eaa986caf7a164431f2cd44bf1c0b34e8382ae473</citedby><cites>FETCH-LOGICAL-c344t-1740dc5ca73d9c37433f5dc1eaa986caf7a164431f2cd44bf1c0b34e8382ae473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Zhu, Wenjun</creatorcontrib><creatorcontrib>Yang, Yu</creatorcontrib><creatorcontrib>Jin, Qiutong</creatorcontrib><creatorcontrib>Chao, Yu</creatorcontrib><creatorcontrib>Tian, Longlong</creatorcontrib><creatorcontrib>Liu, Jingjing</creatorcontrib><creatorcontrib>Dong, Ziliang</creatorcontrib><creatorcontrib>Liu, Zhuang</creatorcontrib><title>Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy</title><title>Nano research</title><addtitle>Nano Res</addtitle><description>Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn
2+
and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope,
99m
Tc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic
in vivo
antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications.</description><subject>Anticancer properties</subject><subject>Antitumor activity</subject><subject>Atomic/Molecular Structure and Spectra</subject><subject>Biodegradability</subject><subject>Biodegradation</subject><subject>Biomedicine</subject><subject>Biotechnology</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Computed tomography</subject><subject>Condensed Matter Physics</subject><subject>Diagnostic systems</subject><subject>Homing</subject><subject>Intravenous administration</subject><subject>Materials Science</subject><subject>Medical imaging</subject><subject>Metal-organic frameworks</subject><subject>Nanotechnology</subject><subject>Oxygen production</subject><subject>Photodynamic therapy</subject><subject>Photon emission</subject><subject>Polyethylene glycol</subject><subject>Porphyrins</subject><subject>Radioisotopes</subject><subject>Research Article</subject><subject>Single photon emission computed tomography</subject><subject>Singlet oxygen</subject><subject>Tomography</subject><subject>Two dimensional materials</subject><subject>Zinc</subject><issn>1998-0124</issn><issn>1998-0000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp9kc1OwzAQhC0EEqXwANwscTb4L3FyRBV_UiUu5WxtHSdNSexgp6r6BLw2rgLiBHvY3cM3I40GoWtGbxml6i4yzpUklBWEc8kJP0EzVpYFoWlOf37G5Tm6iHFLac6ZLGboc7X3pGp762LrHXS4tyN0xIcGXGtIHaC3ex_eMUQMeOfaj53F48YGcD6OrcEuPWToYKx96HFa2O1MZyHgtoemdQ0GV2GzsX3CNn701cFBn4QGnLFh8hoOl-ishi7aq-87R2-PD6vFM1m-Pr0s7pfECClHwpSklckMKFGVRigpRJ1VhlmAssgN1ApYLqVgNTeVlOuaGboW0hai4GClEnN0M_kOwacocdRbvwspeNQ8oyLjZcGzfykmFM2VVHmi2ESZ4GMMttZDSKHDQTOqj63oqRWdWtHHVjRPGj5pYmJdY8Ov89-iL31AkdM</recordid><startdate>20190601</startdate><enddate>20190601</enddate><creator>Zhu, 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metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy</title><author>Zhu, Wenjun ; Yang, Yu ; Jin, Qiutong ; Chao, Yu ; Tian, Longlong ; Liu, Jingjing ; Dong, Ziliang ; Liu, Zhuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-1740dc5ca73d9c37433f5dc1eaa986caf7a164431f2cd44bf1c0b34e8382ae473</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Anticancer properties</topic><topic>Antitumor activity</topic><topic>Atomic/Molecular Structure and Spectra</topic><topic>Biodegradability</topic><topic>Biodegradation</topic><topic>Biomedicine</topic><topic>Biotechnology</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Chemistry and Materials Science</topic><topic>Chemotherapy</topic><topic>Computed tomography</topic><topic>Condensed Matter Physics</topic><topic>Diagnostic 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Zhuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy</atitle><jtitle>Nano research</jtitle><stitle>Nano Res</stitle><date>2019-06-01</date><risdate>2019</risdate><volume>12</volume><issue>6</issue><spage>1307</spage><epage>1312</epage><pages>1307-1312</pages><issn>1998-0124</issn><eissn>1998-0000</eissn><abstract>Nanoscale metal organic frameworks (NMOFs) with porous structure and inherent biodegradability are attractive nanomedicine platforms. In addition to conventional particulate NMOFs, two-dimensional (2D) NMOFs are emerging as a unique type of NMOFs which however have been relatively less explored for nanomedicine applications. Herein, 2D-NMOFs composed of Zn
2+
and tetrakis(4-carboxyphenyl) porphyrin (TCPP) are fabricated and functionalized with polyethylene glycol (PEG). Compared to their particulate counterpart, such 2D-NMOFs show greatly increased drug loading capacity and enhanced light-triggered singlet oxygen production, promising for chemotherapy and photodynamic therapy (PDT), respectively. Utilizing the porphyrin structure of TCPP, our 2D-NMOFs could be labeled with a diagnostic radioisotope,
99m
Tc, for single photon emission computer tomography (SPECT) imaging, which reveals efficient tumor homing of those 2D-NMOFs upon intravenous injection. While offering a remarkable synergistic
in vivo
antitumor effect for the combined chemo-PDT, such 2D-NMOFs show efficient biodegradation and rapid renal clearance. Our work presents the great promise of 2D-NMOFs for nanomedicine applications.</abstract><cop>Beijing</cop><pub>Tsinghua University Press</pub><doi>10.1007/s12274-018-2242-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1998-0124 |
| ispartof | Nano research, 2019-06, Vol.12 (6), p.1307-1312 |
| issn | 1998-0124 1998-0000 |
| language | eng |
| recordid | cdi_proquest_journals_2503529825 |
| source | Springer Nature |
| subjects | Anticancer properties Antitumor activity Atomic/Molecular Structure and Spectra Biodegradability Biodegradation Biomedicine Biotechnology Cancer Cancer therapies Chemistry and Materials Science Chemotherapy Computed tomography Condensed Matter Physics Diagnostic systems Homing Intravenous administration Materials Science Medical imaging Metal-organic frameworks Nanotechnology Oxygen production Photodynamic therapy Photon emission Polyethylene glycol Porphyrins Radioisotopes Research Article Single photon emission computed tomography Singlet oxygen Tomography Two dimensional materials Zinc |
| title | Two-dimensional metal-organic-framework as a unique theranostic nano-platform for nuclear imaging and chemo-photodynamic cancer therapy |
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