Functionalization of AuMSS nanorods towards more effective cancer therapies

The application of nanoparticles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among th...

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Bibliographic Details
Published in:Nano research 2019-04, Vol.12 (4), p.719-732
Main Authors: Rodrigues, Carolina F., Jacinto, Telma A., Moreira, André F., Costa, Elisabete C., Miguel, Sónia P., Correia, Ilídio J.
Format: Article
Language:English
Subjects:
Atomic/Molecular Structure and Spectra
Biocompatibility
Biomedicine
Biotechnology
Blood circulation
Cancer
Cancer therapies
Chemical properties
Chemistry and Materials Science
Condensed Matter Physics
Drug delivery
Drug delivery systems
Drugs
Gold
Hyperthermia
Infrared radiation
Materials Science
Nanoparticles
Nanorods
Nanotechnology
Near infrared radiation
Organic chemistry
Payloads
Pharmacokinetics
Pharmacology
Review Article
Silica
Silicon dioxide
Therapy
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Summary:The application of nanoparticles as selective drug delivery platforms arises as one the most promising therapeutic strategies in the biomedical field. Such systems can encapsulate drugs, prevent its premature degradation, transport and promote the drugs specific delivery to the target site. Among the different nanostructures, gold-core mesoporous silica shell (AuMSS) nanorods have been one of the most explored due to their unique physical and chemical properties. The mesoporous silica biocompatibility, high surface area that can be easily functionalized, tubular pores that can store the drugs, conjugated with the intrinsic capacity of gold nanorod to absorb near-infrared radiation, allows the combination of hyperthermia (i.e., photothermal effect) with drug delivery, making them a nanoplatforms with a huge potential for cancer therapy. Nevertheless, the successful application of AuMSS nanoparticles as an effective cancer nanomedicine is hindered by the uncontrolled release of the therapeutic payloads, limited blood circulation time and unfavorable pharmacokinetics. In this review, an overview of the modifications performed to improve the AuMSS nanorods application in nanomedicine is provided, highlighting the practical approaches that enhanced the AuMSS nanorods targeting, responsiveness to different stimuli, and blood circulation time. Further, the basics of AuMSS nanorods synthesis procedures, general properties, and its application in cancer therapy are also described.
ISSN:1998-0124
1998-0000
DOI:10.1007/s12274-019-2286-y