Three-Component Condencations of 3-Amino-1,2,4-triazoles, Methyl 3-(2-Cycloamino-4-methylpyrimidin-5-yl)-3-oxopropionoates, and a Series of C1 Synthons as a Convenient Approach to Pyrimidin-5-yl-1,2,4-triazolo[1,5-a]pyrimidines

A convenient synthetic approach to polysubstituted dihydrogenated or heteroaromatic 1,2,4-triazolo[1,5- a ]pyrimidines derivatives containing at position 5 a 4-methylpyrimidine moiety bearing a cycloamino substituent at position 2 and linked to the triazolopyrimidine bicycle through its position 5 w...

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Bibliographic Details
Published in:Russian journal of organic chemistry 2021-02, Vol.57 (2), p.219-225
Main Authors: Potapov, A. Yu, Polikarchuk, V. A., Paponov, B. V., Ledeneva, I. V., Stolpovskaya, N. V., Kryl’skii, D. V., Shikhaliev, Kh. S.
Format: Article
Language:English
Subjects:
Aldehydes
Bicycles
Chemistry
Chemistry and Materials Science
Organic Chemistry
Pyrimidines
Triazoles
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Summary:A convenient synthetic approach to polysubstituted dihydrogenated or heteroaromatic 1,2,4-triazolo[1,5- a ]pyrimidines derivatives containing at position 5 a 4-methylpyrimidine moiety bearing a cycloamino substituent at position 2 and linked to the triazolopyrimidine bicycle through its position 5 was developed. The approach involves unusual three-component condensations of 3-amino-1,2,4-triazoles, methyl 3-(2-R-4-methylpyrimidin-5-yl)-3-oxopropionates, and a series of C 1 synthons whose synthetic equivalents are a series of aromatic aldehydes, triethyl orthoformate, or DMFDMA were used as of C 1 synthons.
ISSN:1070-4280
1608-3393
DOI:10.1134/S1070428021020123