Carbazate functionalized cellulose beads as potential scavengers specific for carbonylated proteins

Scavenging carbonylated proteins that are toxic substances inducing various diseases attract the most attention in the field of blood purification. In our study, functionalized cellulose beads modified by carbazate groups as affinity ligands of carbonyls were prepared for specific scavenging of carb...

Full description

Saved in:
Bibliographic Details
Published in:Cellulose (London) 2021-03, Vol.28 (5), p.3029-3039
Main Authors: Huang, Lanli, Zhou, Xiuqiong, Feng, Xianjing, Nong, Jieou, Yan, Guohua, Zheng, Li, Gao, Ming
Format: Article
Language:English
Subjects:
Aldehydes
Beads
Bioorganic Chemistry
Carbonyls
Cellulose
Ceramics
Chemistry
Chemistry and Materials Science
Composites
Electrophoresis
Glass
Natural Materials
Organic Chemistry
Original Research
Physical Chemistry
Polymer Sciences
Proteins
Scavenging
Stability analysis
Substitution reactions
Sustainable Development
Thermal stability
Toxic diseases
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Scavenging carbonylated proteins that are toxic substances inducing various diseases attract the most attention in the field of blood purification. In our study, functionalized cellulose beads modified by carbazate groups as affinity ligands of carbonyls were prepared for specific scavenging of carbonylated proteins based on the carbazate-aldehyde/ ketone reaction. Results showed that the carbazate-functionalized cellulose beads with different degrees of substitution (DS) maintained the original multi-porous structure with the diameter of about 50 μm and thermal stability. Spectroscopic and gel electrophoresis analysis indicated that the modified cellulose beads could effectively scavenge carbonylated proteins and the scavenging effects increased with the increase of DS. Thus, the carbazate functionalized cellulose beads may be developed as fillers in the column for the scavenging of carbonylated proteins.
ISSN:0969-0239
1572-882X
DOI:10.1007/s10570-020-03659-9