Parenteral Nutrition and Cardiotoxicity

Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disea...

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Bibliographic Details
Published in:Cardiovascular toxicology 2021-04, Vol.21 (4), p.265-271
Main Authors: van Nispen, Johan, Voigt, Marcus, Song, Eric, Armstrong, Austin, Fedorova, Margarita, Murali, Vidul, Krebs, Joseph, Samaddar, Ashish, Manithody, Chandrashekhara, Jain, Ajay
Format: Article
Language:English
Subjects:
Animals
Antioxidants - therapeutic use
B cells
Biomedical and Life Sciences
Biomedicine
Biopterins - analogs & derivatives
Biopterins - therapeutic use
Cardiology
Cardiotoxicity
Cardiovascular system
Case reports
Enteral nutrition
Heart Diseases - drug therapy
Heart Diseases - etiology
Heart Diseases - metabolism
Heart Diseases - physiopathology
Humans
Liver diseases
Nutrition
Nutrition therapy
Oxidative Stress - drug effects
Parenteral nutrition
Parenteral Nutrition - adverse effects
Pharmacology/Toxicology
Reactive Oxygen Species - metabolism
Receptors, G-Protein-Coupled - agonists
Receptors, G-Protein-Coupled - metabolism
Side effects
Signal Transduction
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Summary:Parenteral nutrition (PN) is a life-saving nutritional therapy for those situations when patients are unable to receive enteral nutrition. However, despite a multitude of benefits offered by PN, it is associated with a variety of side effects, most notably parenteral nutrition-associated liver disease (PNALD). Adverse effects of PN on other organ systems, such as brain and cardiovascular system, have been poorly studied. There have been several case reports, studies, and a recent animal study highlighting cardiotoxic effects of PN; however, much remains unclear about the underlying mechanisms causing cardiac damage. In this review, we propose a series of potential mechanisms behind PN-associated heart injury, and we provide an overview of therapeutic strategies and recent scientific advances.
ISSN:1530-7905
1559-0259
DOI:10.1007/s12012-021-09638-1