Antibodies with potent and broad neutralizing activity against antigenically diverse and highly transmissible SARS-CoV-2 variants

The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent do...

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Bibliographic Details
Published in:bioRxiv 2021-03
Main Authors: Wang, Lingshu, Zhou, Tongqing, Zhang, Yi, Yang, Eun Sung, Schramm, Chaim A, Shi, Wei, Pegu, Amarendra, Oloninyi, Olamide K, Ransier, Amy, Darko, Samuel, Narpala, Sandeep R, Hatcher, Christian, Martinez, David R, Tsybovsky, Yaroslav, Phung, Emily, Abiona, Olubukola M, Cale, Evan M, Chang, Lauren A, Corbett, Kizzmekia S, DiPiazza, Anthony T, Gordon, Ingelise J, Leung, Kwanyee, Liu, Tracy, Mason, Rosemarie D, Nazzari, Alexandra, Novik, Laura, Olia, Adam S, Doria-Rose, Nicole A, Stephens, Tyler, Stringham, Christopher D, Talana, Chloe Adrienna, Teng, I-Ting, Wagner, Danielle, Widge, Alicia T, Zhang, Baoshan, Roederer, Mario, Ledgerwood, Julie E, Ruckwardt, Tracy J, Gaudinski, Martin R, Baric, Ralph S, Graham, Barney S, McDermott, Adrian B, Douek, Daniel C, Kwong, Peter D, Mascola, John R, Sullivan, Nancy J, Misasi, John
Format: Article
Language:English
Subjects:
Antibodies
Patent applications
Severe acute respiratory syndrome coronavirus 2
Structure-function relationships
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Summary:The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies. We identify four receptor-binding domain targeting antibodies from three early-outbreak convalescent donors with potent neutralizing activity against 12 variants including the B.1.1.7 and B.1.351 VOCs. Two of them are ultrapotent, with sub-nanomolar neutralization titers (IC50
ISSN:2692-8205
DOI:10.1101/2021.02.25.432969