Luteolin supplementation ameliorates cobalt-induced oxidative stress and inflammation by suppressing NF-кB/Kim-1 signaling in the heart and kidney of rats

•Cobalt induces oxidative stress and up-regulation of NF-кB in heart and kidneys of rats.•Luteolin’s suppression of cobalt-induced injury involved suppression of oxidative damage and down-regulation of NF-кB.•Luteolin exhibited marked anti-inflammatory activity with reduction of serum myeloperoxidas...

Full description

Saved in:
Bibliographic Details
Published in:Environmental toxicology and pharmacology 2020-11, Vol.80, p.103488, Article 103488
Main Authors: Oyagbemi, Ademola Adetokunbo, Akinrinde, Akinleye Stephen, Adebiyi, Olamide Elizabeth, Jarikre, Theophilus Aghogho, Omobowale, Temidayo Olutayo, Ola-Davies, Olufunke Eunice, Saba, Adebowale Benard, Emikpe, Benjamin Obukowho, Adedapo, Adeolu Alex
Format: Article
Language:English
Subjects:
Acute Kidney Injury - chemically induced
Acute Kidney Injury - drug therapy
Acute Kidney Injury - metabolism
Acute Kidney Injury - pathology
Animals
Anti-Inflammatory Agents - pharmacology
Anti-Inflammatory Agents - therapeutic use
Cardiomyopathy
Cell Adhesion Molecules - metabolism
Ceramics industry
Cobalt
Cobalt - toxicity
Cobalt chloride
Diamond polishing
Dietary Supplements
Gallic acid
Gallic Acid - pharmacology
Gallic Acid - therapeutic use
Glutathione
Glutathione peroxidase
Glutathione transferase
Heart
Hydrogen peroxide
Kidney - drug effects
Kidney - metabolism
Kidney - pathology
Kidney injury
Kidney injury molecule-1
Kidneys
Luteolin
Luteolin - pharmacology
Luteolin - therapeutic use
Male
Malondialdehyde
Metal industry
Myocardium - metabolism
Myocardium - pathology
NF-kappa B - metabolism
NF-κB protein
Nitric oxide
Nuclear factor-κappa B
Oxidative stress
Oxidative Stress - drug effects
Peroxidase
Rats, Wistar
Signal Transduction - drug effects
Supplements
Toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Cobalt induces oxidative stress and up-regulation of NF-кB in heart and kidneys of rats.•Luteolin’s suppression of cobalt-induced injury involved suppression of oxidative damage and down-regulation of NF-кB.•Luteolin exhibited marked anti-inflammatory activity with reduction of serum myeloperoxidase activity. Cobalt-induced cardiomyopathy and renal toxicity have been reported in workers in processing plants, hard metal industries, diamond polishing and manufacture of ceramics. This study was designed to investigate the influence of Luteolin supplementation on cobalt-induced cardiac and renal toxicity in rats. Exposure of rats to cobalt chloride (CoCl2) alone caused significant (p 
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2020.103488