Identification of Eltrombopag as a Repurposing Drug Against Staphylococcus epidermidis and its Biofilms

Staphylococcus epidermidis is a common cause of nosocomial infections, and readily adheres to medical apparatus to form biofilms consisting of highly resistant persister cells. Owing to the refractory infections caused by S. epidermidis biofilms and persisters in immunosuppressed patients, it is cru...

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Bibliographic Details
Published in:Current microbiology 2021-04, Vol.78 (4), p.1159-1167
Main Authors: Zhu, Juan, She, Pengfei, Fu, Juhua, Peng, Canhui, Wu, Yong
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Antibiotics
Antiinfectives and antibacterials
Antimicrobial agents
Benzoates
Biofilms
Biomedical and Life Sciences
Biotechnology
Drug Repositioning
Humans
Hydrazines
Life Sciences
Mammalian cells
Mammals
Medical equipment
Microbial Sensitivity Tests
Microbiology
Nosocomial infection
Nosocomial infections
Pharmaceutical Preparations
Planktonic cells
Pyrazoles
Staphylococcus epidermidis
Thrombopoietin
Toxicity
Vancomycin
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Summary:Staphylococcus epidermidis is a common cause of nosocomial infections, and readily adheres to medical apparatus to form biofilms consisting of highly resistant persister cells. Owing to the refractory infections caused by S. epidermidis biofilms and persisters in immunosuppressed patients, it is crucial to develop new antimicrobials. In the present study, we analyzed the antimicrobial effects of the thrombopoietin receptor agonist eltrombopag (EP) against S. epidermidis planktonic cells, biofilms, and persister cells. EP was significantly toxic to S. epidermidis with the minimal inhibitory concentration of 8 μg/ml, and effectively inhibited the biofilms and persisters in a strain-dependent manner. In addition, EP was only mildly toxic to mammalian cells after 12 to 24 h treatment. It also partially synergized with vancomycin against S. epidermidis , which enhanced its antimicrobial effects and reduced its toxicity to mammalian cells. Taken together, EP is a potential antibiotic for treating refractory infections caused by S. epidermidis .
ISSN:0343-8651
1432-0991
DOI:10.1007/s00284-021-02386-z